ArticleAntimicrobial agents and chemotherapy2012
In vitro susceptibility testing of Dientamoeba fragilis.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Treatment outcomes in symptomatic Dientamoeba fragilis infection: a prospective clinical and molecular study.Infection · 2026Observational
- Diversity profiling of xenic cultures ofParasitology · 2020Article
- Article
- Dientamoeba fragilis, the Neglected Trichomonad of the Human Bowel.Clinical microbiology reviews · 2016Review
- In Vitro Antimicrobial Susceptibility Patterns of Blastocystis.Antimicrobial agents and chemotherapy · 2015Article
- Understanding the contribution of environmental factors in the spread of antimicrobial resistance.Environmental health and preventive medicine · 2015Review
- Understanding drug resistance in human intestinal protozoa.Parasitology research · 2015Review
- Epidemiology and geographical distribution of enteric protozoan infections in sydney, australia.Journal of public health research · 2014Article
- Activity of benzimidazoles against Dientamoeba fragilis (Trichomonadida, Monocercomonadidae) in vitro and correlation of beta-tubulin sequences as an indicator of resistance.Parasite (Paris, France) · 2014Article
- Treatment of Dientamoeba fragilis in patients with irritable bowel syndrome.The American journal of tropical medicine and hygiene · 2012Article
- Current treatment options for Dientamoeba fragilis infections.International journal for parasitology. Drugs and drug resistance · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dientamoeba fragilis is a commonly encountered trichomonad which has been implicated as a cause of gastrointestinal disease in humans. Despite the frequency of reports recording infections with this parasite, little research has been undertaken in terms of antimicrobial susceptibility. The aim of this study was to evaluate the susceptibility of D. fragilis to several commonly used antiparasitic agents: diloxanide furoate, furazolidone, iodoquinol, metronidazole, nitazoxanide, ornidazole, paromomycin, secnidazole, ronidazole, tetracycline, and tinidazole. Antibiotic susceptibility testing was performed on four clinical strains of D. fragilis, designated A, E, M, and V, respectively. Molecular testing followed, and all strains were determined to be genotype 1. The activities of antiprotozoal compounds at concentrations ranging from 2 μg/ml to 500 μg/ml were determined via cell counts of D. fragilis trophozoites grown in dixenic culture. Minimum lethal concentrations (MLCs) were as follows: ornidazole, 8 to 16 μg/ml; ronidazole, 8 to 16 μg/ml; tinidazole, 31 μg/ml; metronidazole, 31 μg/ml; secnidazole, 31 to 63 μg/ml; nitazoxanide, 63 μg/ml; tetracycline, 250 μg/ml; furazolidone, 250 to 500 μg/ml; iodoquinol, 500 μg/ml; paromomycin, 500 μg/ml; and diloxanide furoate, >500 μg/ml. This is the first study to report the profiles of susceptibility to a wide range of commonly used treatments for clinical isolates of D. fragilis. Our study indicated 5-nitroimidazole derivatives to be the most active compounds in vitro against D. fragilis.
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Registered trials
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