ArticleImmunobiology2012
Genetic variation in complement regulators and susceptibility to age-related macular degeneration.
Article in Immunobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Increased plasma level of terminal complement complex in AMD patients: potential functional consequences for RPE cells.Frontiers in immunology · 2023Article
- The Role of Osteopontin in Microglia Biology: Current Concepts and Future Perspectives.Biomedicines · 2022Review
- Retinoid analogs and polyphenols as potential therapeutics for age-related macular degeneration.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Complement and human T cell metabolism: Location, location, location.Immunological reviews · 2020Review
- Complement and T Cell Metabolism: Food for Thought.Immunometabolism · 2019Article
- Modulation of three key innate immune pathways for the most common retinal degenerative diseases.EMBO molecular medicine · 2018Review
- Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro.Scientific reports · 2018Article
- Anaphylatoxins Activate CaFrontiers in immunology · 2017Article
- Association of CD59 and CFH polymorphisms with acute anterior uveitis in Chinese population.Eye (London, England) · 2016Article
- Inflammation and its role in age-related macular degeneration.Cellular and molecular life sciences : CMLS · 2016Review
- Complement Activation and Inhibition in Retinal Diseases.Developments in ophthalmology · 2016Review
- Genome-wide association studies: getting to pathogenesis, the role of inflammation/complement in age-related macular degeneration.Cold Spring Harbor perspectives in medicine · 2014Review
- Complement factor B polymorphism (rs641153) and susceptibility to age-related macular degeneration: evidence from published studies.International journal of ophthalmology · 2013Article
- Complement dysregulation in AMD: RPE-Bruch's membrane-choroid.Molecular aspects of medicine · 2012Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesAge-related macular degeneration (AMD) is the commonest cause of blindness in Western populations. Risk is influenced by age, genetic and environmental factors. Complement activation appears to be important in the pathogenesis and associations have been found between AMD and genetic variations in complement regulators such as complement factor H. We therefore investigated other complement regulators for association with AMD.
methodsWe carried out a case-control study to test for association between AMD and single nucleotide polymorphisms (SNPs) spanning the genes encoding complement factor P (CFP, properdin), CD46 (membrane cofactor protein, MCP), CD55 (decay accelerating factor, DAF) and CD59 (protectin). All cases and controls were examined by an ophthalmologist and had independent grading of fundus photographs to confirm their disease status.
results20 SNPs were genotyped in 446 cases and 262 controls. For two SNPs with p-values approaching significance additional subjects were genotyped to increase the numbers to 622 cases and 359 controls. There was no evidence of association between AMD and any of the SNPs typed in CFP, CD46, CD55 or CD59.
conclusionsIn a case-control sample that has shown the well established associations between AMD and variants in CFH, CFB and C3 there was absence of association with SNPs in CFP, CD46, CD55 and CD59. This suggests that these are not important susceptibility genes for AMD.
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