Evidence map›Paper›PMID 22024648›Full record

ReviewTrends in parasitology2011

Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery.

Martin T Swain, Denis M Larkin, Conor R Caffrey, Stephen J Davies, Alex Loukas, Patrick J Skelly, Karl F Hoffmann

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. A comprehensive and critical overview of schistosomiasis vaccine candidates.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021
    Review
  4. Review
  5. Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase fromInternational journal of molecular sciences · 2020
    Article
  6. Article
  7. Article
  8. New research tools for urogenital schistosomiasis.The Journal of infectious diseases · 2015
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. New frontiers in schistosoma genomics and transcriptomics.Journal of parasitology research · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Martin T SwainInstitute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.
Denis M Larkin
Conor R Caffrey
Stephen J Davies
Alex Loukas
Patrick J Skelly
Karl F Hoffmann

Funding

Gene silencing in schistosomes using RNAiR01AI056273 · NIAID · TUFTS UNIVERSITY BOSTON · PI Patrick J Skelly · 2004 to 2026
$7.2M
Functional Characterization of the Schistosome TegumentR56AI056273 · NIAID · TUFTS UNIVERSITY BOSTON · PI SKELLY, PATRICK J · 2021 to 2021
$413k
NIAID NIH HHS AI-056273NIAID NIH HHS R01 AI056273NIAID NIH HHS R56 AI056273Wellcome Trust
6 · The paper itself

Abstract

Schistosoma genomes provide a comprehensive resource for identifying the molecular processes that shape parasite evolution and for discovering novel chemotherapeutic or immunoprophylactic targets. Here, we demonstrate how intragenus and intergenus comparative genomics can be used to drive these investigations forward, illustrate the advantages and limitations of these approaches and review how post-genomic technologies offer complementary strategies for genome characterisation. Although sequencing and functional characterisation of other schistosome/platyhelminth genomes continues to expedite anthelmintic discovery, we contend that future priorities should equally focus on improving assembly quality, and chromosomal assignment, of existing schistosome/platyhelminth genomes.

Indexed as

AnimalsAnthelminticsChromosomesGenome, HelminthGenomicsHumansSchistosomaSchistosomiasisAnthelmintics

Identifiers

PMID22024648
PMCPMC3223292

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.