ArticleJournal of psychiatric research2012
Genetic associations with performance on a behavioral measure of distress intolerance.
Article in Journal of psychiatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Moderators and mediators of the relationship between parental depression and children's emotion dysregulation: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Genetic Variants Associated With Resilience in Human and Animal Studies.Frontiers in psychiatry · 2022Pooled it
- Hyperarousal, Dissociation, Emotion Dysregulation and Re-Experiencing-Towards Understanding Molecular Aspects of PTSD Symptoms.International journal of molecular sciences · 2025Review
- Who disengages from emotion and when? An EMA study of how urgency and distress intolerance relate to daily emotion regulation.Emotion (Washington, D.C.) · 2023Article
- Methylation of the serotonin transporter gene moderates the depressive subjective effect of cocaine.Behavioural brain research · 2022Article
- The Molecular Basis of Resilience: A Narrative Review.Frontiers in psychiatry · 2022Review
- Transactional patterns of depressive symptoms between mothers and adolescents: The role of emotion regulation.Depression and anxiety · 2021Article
- Distress Tolerance as a Familial Vulnerability for Distress-Misery Disorders.Behavior therapy · 2020Article
- Pharmacodynamic Gene Testing in Prader-Willi Syndrome.Frontiers in genetics · 2020Article
- Association between resilience and a functional polymorphism in the serotonin transporter (SLC6A4) gene: A meta-analysis.EXCLI journal · 2020Article
- The Behavioral Approach System (BAS) Model of Vulnerability to Bipolar Disorder: Evidence of a Continuum in BAS Sensitivity across Adolescence.Journal of abnormal child psychology · 2018Article
- The developmental trajectory of perceived stress mediates the relations between distress tolerance and internalizing symptoms among youth.Development and psychopathology · 2017Article
- A Prospective Examination of the Relations Between Emotional Abuse and Anxiety: Moderation by Distress Tolerance.Prevention science : the official journal of the Society for Prevention Research · 2017Article
- Distress Tolerance and Social Support in Adolescence: Predicting Risk for Internalizing and Externalizing Symptoms Following a Natural Disaster.Journal of psychopathology and behavioral assessment · 2016Article
- Genetic and Neuroimaging Features of Personality Disorders: State of the Art.Neuroscience bulletin · 2016Review
- Effects of Gene × Attachment Interaction on Adolescents' Emotion Regulation and Aggressive Hostile Behavior Towards their Mothers during a Computer Game.Frontiers in human neuroscience · 2016Article
- Recent advances in the genetics of emotion regulation: a review.Current opinion in psychology · 2015Article
- Recent Advances in Laboratory Assessment of Emotion Regulation.Current opinion in psychology · 2015Article
- Review of the genetic basis of emotion dysregulation in children and adolescents.World journal of psychiatry · 2015Review
- Development of Ego-Resiliency: Relations to Observed Parenting and Polymorphisms in the Serotonin Transporter Gene During Early Childhood.Social development (Oxford, England) · 2014Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Both theory and empirical evidence support possible associations between two candidate genetic polymorphisms (SLC6A4 5-HTTLPR l/s and COMT Val(158)Met--rs4680 variants) and emotion-regulation difficulties. One particular form of emotion-regulation difficulty, distress intolerance, has been measured using a behavioral assessment in youth; data indicate a relationship with poor psychological functioning. No prior study has investigated genetic influences on emotion-regulation difficulties in youth. As part of a larger longitudinal study on adolescent risk behaviors, 218 10-14 year-old youths from the metropolitan Washington, D.C., area completed a measure of distress intolerance, the Behavioral Indicator of Resilience to Distress (BIRD), and provided saliva samples for DNA extraction and genotyping. Results indicate that those with one or two copies of the s allele of the 5-HTTLPR polymorphism were more likely to perform poorly on the task (i.e., choose to quit) than were those homozygous for the l allele. Participants who were Val allele carriers of the COMT Val(158)Met polymorphism were also more likely to quit the task compared to Met homozygotes. A summative risk allele score was created to combine the two polymorphisms, and each risk allele was associated with a 1.75 fold increased likelihood of quitting the task. Exploratory analyses revealed that emotional abuse moderated the relationship between the 5-HTTLPR and BIRD performance, as well as the genetic risk allele and the BIRD. This is the first investigation of genetic predictors of a behavioral measure of tolerance to distress. Results suggest that distress tolerance is at least partially regulated by specific genetic variants. Implications are discussed.
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