ArticleDevelopmental biology2012
Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 50 citations in OpenAlex.
- Asymmetric division sustains stem cell heterogeneity in the Drosophila testicular niche.Communications biology · 2026Article
- Stem cells resume asymmetric division upon niche re-entry through reactivating the centrosome orientation checkpoint.Communications biology · 2026Article
- Maintenance of niche architecture requires actomyosin and enables proper stem cell signaling and oriented division in the Drosophila testis.Development (Cambridge, England) · 2025Article
- rDNA magnification is a unique feature of germline stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila.Nature communications · 2022Article
- A stochastic model of homeostasis: The roles of noise and nuclear positioning in deciding cell fate.iScience · 2021Article
- Live imaging of the Drosophila ovarian niche shows spectrosome and centrosome dynamics during asymmetric germline stem cell division.Development (Cambridge, England) · 2021Article
- Vaginal & gut microbiota diversity in pregnant women with bacterial vaginosis & effect of oral probiotics: An exploratory study.The Indian journal of medical research · 2021Article
- Emerging mechanisms of asymmetric stem cell division.The Journal of cell biology · 2018Review
- Transient transcriptional silencing alters the cell cycle to promote germline stem cell differentiation in Drosophila.Developmental biology · 2018Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Review
- The PAR proteins: from molecular circuits to dynamic self-stabilizing cell polarity.Development (Cambridge, England) · 2017Review
- Article
- Polycomb Group Gene E(z) Is Required for Spermatogonial Dedifferentiation in Drosophila Adult Testis.Journal of molecular biology · 2017Article
- The Centrioles, Centrosomes, Basal Bodies, and Cilia ofGenetics · 2017Review
- Regulation of Cell Polarity by PAR-1/MARK Kinase.Current topics in developmental biology · 2017Review
- The ins(ide) and outs(ide) of asymmetric stem cell division.Current opinion in cell biology · 2016Review
- Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila.Nature communications · 2016Article
- Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes.Molecular biology of the cell · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Male germline stem cells (GSCs) in Drosophila melanogaster divide asymmetrically by orienting the mitotic spindle with respect to the niche, a microenvironment that specifies stem cell identity. The spindle orientation is prepared during interphase through stereotypical positioning of the centrosomes. We recently demonstrated that GSCs possess a checkpoint ("the centrosome orientation checkpoint") that monitors correct centrosome orientation prior to mitosis to ensure an oriented spindle and thus asymmetric outcome of the division. Here, we show that Par-1, a serine/threonine kinase that regulates polarity in many systems, is involved in this checkpoint. Par-1 shows a cell cycle-dependent localization to the spectrosome, a germline-specific, endoplasmic reticulum-like organelle. Furthermore, the localization of cyclin A, which is normally localized to the spectrosome, is perturbed in par-1 mutant GSCs. Interestingly, overexpression of mutant cyclin A that does not localize to the spectrosome and mutation in hts, a core component of the spectrosome, both lead to defects in the centrosome orientation checkpoint. We propose that the regulation of cyclin A localization via Par-1 function plays a critical role in the centrosome orientation checkpoint.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.