ReviewMolecular aspects of medicine2012
Selenium and asthma.
Review in Molecular aspects of medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Nutrition as a Modifiable Factor in Optimizing Respiratory Health: Evidence from Pulmonary Function Tests.Children (Basel, Switzerland) · 2026Review
- Sex Differences in Oxidative Stress Concerning Allergic Diseases.Biomolecules · 2025Review
- Association between blood heavy metal element and all-cause mortality in asthmatic adults: a cohort study.Scientific reports · 2024Article
- The antioxidant barrier, oxidative/nitrosative stress, and protein glycation in allergy: from basic research to clinical practice.Frontiers in immunology · 2024Review
- The correlation between selenium intake and lung function in asthmatic people: a cross-sectional study.Frontiers in nutrition · 2024Article
- The Role of Diet and Nutrition in Allergic Diseases.Nutrients · 2023Review
- Selenium Species and Fractions in the Rock-Soil-Plant Interface of Maize (International journal of environmental research and public health · 2023Article
- Higher serum selenium concentration is associated with lower risk of all-cause and cardiovascular mortality among individuals with chronic kidney disease: A population-based cohort study of NHANES.Frontiers in nutrition · 2023Article
- Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder.Biological trace element research · 2022Article
- Serum selenium levels and asthma among seafood processing workers in Greenland.International journal of circumpolar health · 2021Article
- Mineral Micronutrients in Asthma.Nutrients · 2021Review
- Lipid Nutrition in Asthma.Cell biochemistry and biophysics · 2021Review
- Review
- Association between toenail zinc concentrations and incidence of asthma among American young adults: The CARDIA study.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2021Article
- Nutraceuticals against Oxidative Stress in Autoimmune Disorders.Antioxidants (Basel, Switzerland) · 2021Review
- Review
- Dietary intake is associated with respiratory health outcomes and DNA methylation in children with asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2017Article
- The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces.Frontiers in immunology · 2017Review
- Trace Elements Status in Sera of Patients with Allergic Asthma.Reports of biochemistry & molecular biology · 2016Article
- Dietary Selenium Levels Affect Selenoprotein Expression and Support the Interferon-γ and IL-6 Immune Response Pathways in Mice.Nutrients · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and prevalence or severity of asthma have not been consistently demonstrated in human studies. This highlights both the complex etiology of human asthma and the inherent problems with correlative nutritional studies. In this review, the different findings in human studies are discussed along with results from limited intervention studies. Mouse models of asthma have provided more definitive results suggesting that the benefits of Se supplementation may depend on an individual's initial Se status. This likely involves T helper cell differentiation and the mechanistic studies that have provided important insight into the effects of Se levels on immune cell function are summarized. Importantly, the benefits and adverse effects of Se supplementation must both be considered in using this nutritional supplement for treating asthma. With this in mind new approaches are discussed that may provide more safe and effective means for using Se supplementation for asthma or other disorders involving inflammation or immunity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.