Evidence map›Paper›PMID 22024020›Full record

ReviewSeminars in cell & developmental biology2012

Determinants of tRNA editing and modification: avoiding conundrums, affecting function.

Zdeněk Paris, Ian M C Fleming, Juan D Alfonzo

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. RNA Editing in Chloroplast: Advancements and Opportunities.Current issues in molecular biology · 2022
    Review
  7. Naturally occurring modified ribonucleosides.Wiley interdisciplinary reviews. RNA · 2020
    Review
  8. Aminoacyl-tRNA synthetases.RNA (New York, N.Y.) · 2020
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. From end to end: tRNA editing at 5'- and 3'-terminal positions.International journal of molecular sciences · 2014
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zdeněk ParisDepartment of Microbiology, The Ohio State University, Columbus, OH 43210, USA.
Ian M C Fleming
Juan D Alfonzo
The Ohio State University · US

Funding

tRNA editing by deamination: Balancing affinity and specifictyR01GM084065 · NIGMS · OHIO STATE UNIVERSITY · PI ALFONZO, JUAN D · 2008 to 2021
$4.0M
NIGMS NIH HHS GM084065NIGMS NIH HHS R01 GM084065
6 · The paper itself

Abstract

In all organisms tRNAs play the essential role of connecting the genetic information found in DNA with the protein synthesis machinery ensuring fidelity during translation. Following transcription tRNAs undergo a number of processing events including numerous post-transcriptional modifications that render a tRNA molecule fully functional. The effects of some modifications go beyond simply affecting tRNA structure and can alter the meaning of the tRNA. This review will summarize the current state of the tRNA editing field, highlighting how editing affects tRNA structure and function in various organisms. It will also discuss recent data that hints at connections between editing and modification that may be exploited by cells to modulate a tRNA's role in translation.

Indexed as

RNA EditingHumansProtein BiosynthesisRNA, TransferRNA, Transfer

Identifiers

PMID22024020
PMCPMC3345058
OpenAlexW2019520746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.