Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2011
Predictors of abstinence: National Institute of Drug Abuse multisite buprenorphine/naloxone treatment trial in opioid-dependent youth.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00078130 (Bup/Nx - Facilitated Rehab for Opioid Dependent Adolescents), which is not on this map. Cited by 29 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bup/Nx - Facilitated Rehab for Opioid Dependent Adolescents
Who cites it
29 citing papers in PubMed, 7 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Analysis of genetic and clinical factors associated with buprenorphine response.Drug and alcohol dependence · 2021Pooled it
- Adherence to and Retention in Medications for Opioid Use Disorder Among Adolescents and Young Adults.Epidemiologic reviews · 2020Pooled it
- Pharmacological therapies for management of opium withdrawal.The Cochrane database of systematic reviews · 2018Pooled it
- Buprenorphine for managing opioid withdrawal.The Cochrane database of systematic reviews · 2017Pooled it
- Discontinuation of buprenorphine maintenance therapy: perspectives and outcomes.Journal of substance abuse treatment · 2015Pooled it
- Maintenance treatments for opiate -dependent adolescents.The Cochrane database of systematic reviews · 2014Pooled it
- Detoxification treatments for opiate dependent adolescents.The Cochrane database of systematic reviews · 2014Pooled it
- The efficacy of two adolescent substance abuse treatments and the impact of comorbid depression: results of a small randomized controlled trial.Psychiatric rehabilitation journal · 2015Trial
- Initial response as a predictor of 12-week buprenorphine-naloxone treatment response in a prescription opioid-dependent population.The Journal of clinical psychiatry · 2015Trial
- Predictors of buprenorphine initial outpatient maintenance and dose taper response among non-treatment-seeking heroin dependent volunteers.Drug and alcohol dependence · 2015Trial
- Achieving cannabis cessation -- evaluating N-acetylcysteine treatment (ACCENT): design and implementation of a multi-site, randomized controlled study in the National Institute on Drug Abuse Clinical Trials Network.Contemporary clinical trials · 2014Trial
- Association of cannabis use with opioid outcomes among opioid-dependent youth.Drug and alcohol dependence · 2013Trial
- Predictors of attrition with buprenorphine/naloxone treatment in opioid dependent youth.Addictive behaviors · 2012Trial
- Interest in using buprenorphine-naloxone among a prospective cohort of street-involved young people in Vancouver, Canada.Journal of substance use and addiction treatment · 2023Article
- Substance use severity as a predictor for receiving medication for opioid use disorder among adolescents: An analysis of the 2019 TEDS.Drug and alcohol dependence · 2023Article
- Launching Relationship-Oriented Behavioral Services for Youth Opioid Use Disorder: Innovations in Medication Decision-Making and Adherence Planning.Child & family behavior therapy · 2023Article
- Cannabis use and opioid relapse: An exploratory survival analysis of prospectively collected data.Frontiers in psychiatry · 2022Article
- Buprenorphine Treatment By Primary Care Providers, Psychiatrists, Addiction Specialists, And Others.Health affairs (Project Hope) · 2020Article
- Opioid substitution treatment and heroin dependent adolescents: reductions in heroin use and treatment retention over twelve months.BMC pediatrics · 2018Article
- Medication-assisted treatment for youth with opioid use disorder: Current dilemmas and remaining questions.The American journal of drug and alcohol abuse · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo examine predictors of opioid abstinence in buprenorphine/naloxone (Bup/Nal)-assisted psychosocial treatment for opioid-dependent youth.
methodSecondary analyses were performed of data from 152 youth (15-21 years old) randomly assigned to 12 weeks of extended Bup/Nal therapy or up to 2 weeks of Bup/Nal detoxification with weekly individual and group drug counseling. Logistic regression models were constructed to identify baseline and during-treatment predictors of opioid-positive urine (OPU) at week 12. Predictors were selected based on significance or trend toward significance (i.e., p < .1), and backward stepwise selection was used, controlling for treatment group, to produce final independent predictors at p ≤ .05.
resultsYouth presenting to treatment with previous 30-day injection drug use and more active medical/psychiatric problems were less likely to have a week-12 OPU. Those with early treatment opioid abstinence (i.e., weeks 1 and 2) and those who received additional nonstudy treatments during the study were less likely to have a week-12 OPU and those not completing 12 weeks of treatment were more likely to have an OPU.
conclusionsYouth with advanced illness (i.e., reporting injection drug use and additional health problems) and those receiving ancillary treatments to augment study treatment were more likely to have lower opioid use. Treatment success in the first 2 weeks and completion of 12 weeks of treatment were associated with lower rates of OPU. These findings suggest that youth with advanced illness respond well to Bup/Nal treatment and identify options for tailoring treatment for opioid-dependent youth presenting at community-based settings. CLINICAL TRIAL REGISTRATION INFORMATION: Buprenorphine/Naloxone-Facilitated Rehabilitation for Opioid Dependent Adolescents; http://www.clinicaltrials.gov; NCT00078130.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.