ArticleMolecular & cellular proteomics : MCP2012
Quantitative proteomics reveals new insights into erythrocyte invasion by Plasmodium falciparum.
Article in Molecular & cellular proteomics : MCP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Integrative Transcriptome and Proteome Analysis Identifies Major Molecular Regulation Pathways Involved in Ramie (Plants (Basel, Switzerland) · 2020Article
- Transcriptome and proteome analyses reveal the regulatory networks and metabolite biosynthesis pathways during the development ofComputational and structural biotechnology journal · 2020Article
- Differential protein expression analysis following olfactory learning in Apis cerana.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Article
- P-selectin is a host receptor for Plasmodium MSP7 ligands.Malaria journal · 2015Article
- Integration of the proteome and transcriptome reveals multiple levels of gene regulation in the rice dl2 mutant.Frontiers in plant science · 2015Article
- Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers.PloS one · 2014Article
- Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development.Journal of proteome research · 2013Article
- Deletion of Synechocystis sp. PCC 6803 leader peptidase LepB1 affects photosynthetic complexes and respiration.Molecular & cellular proteomics : MCP · 2013Article
- Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum.Nature communications · 2013Article
- Article
- Parasites, proteomes and systems: has Descartes' clock run out of time?Parasitology · 2012Review
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6 authors.
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Abstract
Differential expression of ligands in the human malaria parasite Plasmodium falciparum enables it to recognize different receptors on the erythrocyte surface, thereby providing alternative invasion pathways. Switching of invasion from using sialated to nonsialated erythrocyte receptors has been linked to the transcriptional activation of a single parasite ligand. We have used quantitative proteomics to show that in addition to this single known change, there are a significant number of changes in the expression of merozoite proteins that are regulated independent of transcription during invasion pathway switching. These results demonstrate a so far unrecognized mechanism by which the malaria parasite is able to adapt to variations in the host cell environment by post-transcriptional regulation.
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