ArticleActa biomaterialia2012
Antibacterial and cell-adhesive polypeptide and poly(ethylene glycol) hydrogel as a potential scaffold for wound healing.
Article in Acta biomaterialia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 184 citations in OpenAlex.
- Hydrogels for Healing Radiation-Injured Tissues and Organs.Gels (Basel, Switzerland) · 2026Review
- Advanced biomaterial strategies for overcoming age-associated wound healing impairments.APL bioengineering · 2025Review
- Exploration of 4D Printing and its Applications in the Biomedical Sciences.Current pharmaceutical design · 2025Review
- The Effects of Synthetic Polymers on the Release Patterns of Bupivacaine Hydrochloride from Sodium Hyaluronate Hydrogels.Biomedicines · 2024Article
- A NHScientific reports · 2024Article
- Polymer-Based Wound Dressings Loaded with Essential Oil for the Treatment of Wounds: A Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery.Pharmaceutics · 2023Review
- Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications.Gels (Basel, Switzerland) · 2023Review
- Herbal molecule-mediated dual network hydrogels with adhesive and antibacterial properties for strain and pressure sensing.RSC advances · 2023Article
- Antibacterial Soy Protein Isolate Prepared by Quaternization.International journal of molecular sciences · 2022Article
- Antibacterial biomaterials for skin wound dressing.Asian journal of pharmaceutical sciences · 2022Review
- Emerging Fabrication Strategies of Hydrogels and Its Applications.Gels (Basel, Switzerland) · 2022Review
- Investigation of the 3D Printability of Covalently Cross-Linked Polypeptide-Based Hydrogels.ACS omega · 2022Article
- Polymer-Based Constructs for Flexor Tendon Repair: A Review.Polymers · 2022Review
- Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing.Bioactive materials · 2022Article
- A structure-supporting, self-healing, and high permeating hydrogel bioink for establishment of diverse homogeneous tissue-like constructs.Bioactive materials · 2021Article
- Molecular engineering of antimicrobial peptide (AMP)-polymer conjugates.Biomaterials science · 2021Review
- A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems.Bioengineering (Basel, Switzerland) · 2021Review
- Poly(α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives.Bioactive materials · 2021Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The ideal wound-healing scaffold should provide the appropriate physical and mechanical properties to prevent secondary infection, as well as an excellent physiological environment to facilitate cell adhesion, proliferation and/or differentiation. Therefore, we developed a synthetic cell-adhesive polypeptide hydrogel with inherent antibacterial activity. A series of polypeptides, poly(Lys)(x)(Ala)(y) (x+y=100), with varied hydrophobicity via metal-free ring-opening polymerization of NCA-Lys(Boc) and NCA-Ala monomers (NCA=N-carboxylic anhydride) mediated by hexamethyldisilazane (HMDS) were synthesized. These polypeptides were cross-linked with 6-arm polyethylene glycol (PEG)-amide succinimidyl glutarate (ASG) (M(w)=10K) to form hydrogels with a gelation time of five minutes and a storage modulus (G') of 1400-3000 Pa as characterized by rheometry. The hydrogel formed by cross-linking of poly(Lys)(60)(Ala)(40) (5 wt.%) and 6-arm PEG-ASG (16 wt.%) (Gel-III) exhibited cell adhesion and cell proliferation activities superior to other polypeptide hydrogels. In addition, Gel-III displays significant antibacterial activity against Escherichia coli JM109 and Staphylococcus aureus ATCC25923. Thus, we have developed a novel, cell-adhesive hydrogel with inherent antibacterial activity as a potential scaffold for cutaneous wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.