ArticleNano letters2011
Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.
Article in Nano letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
142 citing papers in PubMed, 547 citations in OpenAlex.
- The two sides of 2D materials properties: a perspective on balancing air quality applications with environmental and health risks of 2D materials.Environmental science. Advances · 2026Review
- Universal Mechanochemical One-Pot Synthesis of Hybrid Two-Dimensional Nanomaterials With Metal Nanoparticles.ChemSusChem · 2026Article
- Cell Toxicity and Autophagy in A549 Cells Treated With Surface-Functionalized Graphene Derivatives.Journal of applied toxicology : JAT · 2026Article
- Advances in the Application of Graphene and Its Derivatives in Drug Delivery Systems.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Antimicrobial Effect of Graphene in Dentistry: A Scoping Review.Dentistry journal · 2025Review
- Physico-chemically different carbon nanomaterials may elicit similar inflammatory molecular pathways within the lungs of mice.Toxicology research · 2025Article
- Exploring 2D Graphene-Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective.Small science · 2025Article
- Intramuscular Reactivity of the Modified Graphene Oxides and Their Bio-Reactivity in Aging Muscle.Journal of functional biomaterials · 2025Article
- Application of the Tier 3 NIOSH occupational exposure banding process for the graphene family of nanomaterials: A case study.Journal of occupational and environmental hygiene · 2025Article
- Preclinical evaluation of polymer encapsulated carbon-based nano and microparticles for sentinel lymph node tattooing.Scientific reports · 2024Article
- Graphene and its hybrid nanocomposite: A Metamorphoses elevation in the field of tissue engineering.Heliyon · 2024Review
- Melanin-Based Nanoparticles for Lymph Node Tattooing: Experimental, Histopathological and Ultrastructural Study.Nanomaterials (Basel, Switzerland) · 2024Article
- Reduced Graphene-Oxide-Doped Elastic Biodegradable Polyurethane Fibers for Cardiomyocyte Maturation.ACS biomaterials science & engineering · 2024Article
- [Immunogenic and toxic effects of graphene oxide nanoparticles in mouse skeletal muscles and human red blood cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Review
- Comprehensive Assessment of Graphene Oxide Nanoparticles: Effects on Liver Enzymes and Cardiovascular System in Animal Models and Skeletal Muscle Cells.Nanomaterials (Basel, Switzerland) · 2024Article
- Applications of Graphene Family Nanomaterials in Regenerative Medicine: Recent Advances, Challenges, and Future Perspectives.International journal of nanomedicine · 2024Review
- Article
- Recent advances in nanoantibiotics against multidrug-resistant bacteria.Nanoscale advances · 2023Review
- Efficient skin interactions of graphene derivatives: challenge, opportunity or both?Nanoscale advances · 2023Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
To facilitate the proposed use of graphene and its derivative graphene oxide (GO) in widespread applications, we explored strategies that improve the biocompatibility of graphene nanomaterials in the lung. In particular, solutions of aggregated graphene, Pluronic dispersed graphene, and GO were administered directly into the lungs of mice. The introduction of GO resulted in severe and persistent lung injury. Furthermore, in cells GO increased the rate of mitochondrial respiration and the generation of reactive oxygen species, activating inflammatory and apoptotic pathways. In contrast, this toxicity was significantly reduced in the case of pristine graphene after liquid phase exfoliation and was further minimized when the unoxidized graphene was well-dispersed with the block copolymer Pluronic. Our results demonstrate that the covalent oxidation of graphene is a major contributor to its pulmonary toxicity and suggest that dispersion of pristine graphene in Pluronic provides a pathway for the safe handling and potential biomedical application of two-dimensional carbon nanomaterials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.