ReviewCurrent stem cell research & therapy2012
Troika of the mouse blastocyst: lineage segregation and stem cells.
Review in Current stem cell research & therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Epitranscriptomic regulation of mRNA stability in pivotal transcription factors modulates the second cell fate decision.Nature communications · 2026Article
- Single-cell omics uncover gene dynamics shaping embryonic and extra embryonic lineages in pig blastocysts.iScience · 2026Article
- mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo.Cell & bioscience · 2023Article
- Developmental Hurdles That Can Compromise Pregnancy during the First Month of Gestation in Cattle.Animals : an open access journal from MDPI · 2023Review
- Fluorescent Reporters Distinguish Stem Cell Colony Subtypes During Somatic Cell Reprogramming.Cellular reprogramming · 2022Article
- Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development.Physiological reports · 2022Article
- Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development.Development (Cambridge, England) · 2018Article
- PDGFRA Is Not Essential for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines.Stem cell reports · 2017Article
- Novel role of immature myeloid cells in formation of new lymphatic vessels associated with inflammation and tumors.Journal of leukocyte biology · 2017Review
- Article
- Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos.Scientific reports · 2016Article
- A rapid and efficient 2D/3D nuclear segmentation method for analysis of early mouse embryo and stem cell image data.Stem cell reports · 2014Article
- PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst.Stem cells (Dayton, Ohio) · 2013Article
- Derivation of extraembryonic endoderm stem (XEN) cells from mouse embryos and embryonic stem cells.Nature protocols · 2013Article
- Anatomy of a blastocyst: cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo.Genesis (New York, N.Y. : 2000) · 2013Review
- FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse.Development (Cambridge, England) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The initial period of mammalian embryonic development is primarily devoted to cell commitment to the pluripotent lineage, as well as to the formation of extraembryonic tissues essential for embryo survival in utero. This phase of development is also characterized by extensive morphological transitions. Cells within the preimplantation embryo exhibit extraordinary cell plasticity and adaptation in response to experimental manipulation, highlighting the use of a regulative developmental strategy rather than a predetermined one resulting from the non-uniform distribution of maternal information in the cytoplasm. Consequently, early mammalian development represents a useful model to study how the three primary cell lineages; the epiblast, primitive endoderm (also referred to as the hypoblast) and trophoblast, emerge from a totipotent single cell, the zygote. In this review, we will discuss how the isolation and genetic manipulation of murine stem cells representing each of these three lineages has contributed to our understanding of the molecular basis of early developmental events.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.