ReviewAnnals of the New York Academy of Sciences2011
Neuromodulation of reward-based learning and decision making in human aging.
Review in Annals of the New York Academy of Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03512171 (Dopaminergic Neuromodulation of Decision Making in Young and Middle-Aged Adults), which is not on this map. Cited by 103 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dopaminergic Neuromodulation of Decision Making in Young and Middle-Aged Adults
Who cites it
103 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis.Neurobiology of aging · 2017Pooled it
- Age differences in risky choice: a meta-analysis.Annals of the New York Academy of Sciences · 2011Pooled it
- Comparing the streamlined psychotherapy "Engage" with problem-solving therapy in late-life major depression. A randomized clinical trial.Molecular psychiatry · 2021Trial
- Comparing engage with PST in late-life major depression: a preliminary report.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015Trial
- Dopamine modulates the neural representation of subjective value of food in hungry subjects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Dopamine restores reward prediction errors in old age.Nature neuroscience · 2013Trial
- Stress modulates reinforcement learning in younger and older adults.Psychology and aging · 2013Trial
- Dopamine modulates episodic memory persistence in old age.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Trial
- A neurodevelopmental model of eating disorder risk in midlife to older adulthood.Neuroscience and biobehavioral reviews · 2026Review
- Mistakes matter, age doesn't: task outcome modulates implicit motor adaptation similarly in young and older adults.GeroScience · 2026Article
- Curiosity in younger and older adults: the relationship between information value and memory.Frontiers in cognition · 2026Article
- Association among first-aid literacy, training and life meaning: a KAP study of first-year undergraduates at a comprehensive university in China.Frontiers in psychology · 2026Article
- Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake.Neuropharmacology · 2025Article
- Article
- Heuristic pruning of decision trees at low probabilities and probability discounting in sequential planning in young and older adults.Scientific reports · 2025Article
- Understanding the cognitive factors which contribute to individual differences in financial capacity in aging.Scientific reports · 2025Article
- Diminished State Space Theory of Human Aging.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025Article
- Neural correlates of reduced sensitivity to information about uncertainty during valuation in older adults: An fNIRS study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Association between willingness to exercise and incident disability in older adults: a prospective longitudinal cohort study.European geriatric medicine · 2024Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
In this paper, we review the current literature to highlight relations between age-associated declines in dopaminergic and serotonergic neuromodulation and adult age differences in adaptive goal-directed behavior. Specifically, we focus on evidence suggesting that deficits in neuromodulation contribute to older adults' behavioral disadvantages in learning and decision making. These deficits are particularly pronounced when reward information is uncertain or the task context requires flexible adaptations to changing stimulus-reward contingencies. Moreover, emerging evidence points to age-related differences in the sensitivity to rewarding and aversive outcomes during learning and decision making if the acquisition of behavior critically depends on outcome processing. These age-related asymmetries in outcome valuation may be explained by age differences in the interplay of dopaminergic and serotonergic neuromodulation. This hypothesis is based on recent neurocomputational and psychopharmacological approaches, which suggest that dopamine and serotonin serve opponent roles in regulating the balance between approach behavior and inhibitory control. Studying adaptive regulation of behavior across the adult life span may shed new light on how the aging brain changes functionally in response to its diminishing resources.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.