ArticleThe journal of sexual medicine2012
Characterization of the vasculature supplying the genital tissues in female rats.
Article in The journal of sexual medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 21 citations in OpenAlex.
- Pudendal, but not tibial, nerve stimulation modulates vulvar blood perfusion in anesthetized rodents.International urogynecology journal · 2023Article
- Protective effects of irbesartan and benazepril against vaginal vascular remodeling and fibrosis in female spontaneously hypertensive rats.The Journal of international medical research · 2020Article
- Impact of Immune System Activation and Vascular Impairment on Male and Female Sexual Dysfunction.Sexual medicine reviews · 2019Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionThe internal pudendal arteries are the key resistance vessels controlling the peripheral circulatory component of sexual responses in both male and females. Previous studies in the male rat demonstrated that this vessel has markedly heightened susceptibility to vascular damage compared with other vessels in the body. Evidence suggests that the female may also be susceptible to vascular pathologies contributing to sexual dysfunction.
aimThe aim of this study is to characterize the anatomical, morphological, and functional properties of the pudendal artery in female rats.
methodsThe pelvic arteries in young Sprague-Dawley female rats were dissected to generate a composite representation of the vascular gross anatomy. Morphometry was performed on perfusion-fixed pudendal arteries whereas others were mounted in a wire myograph to assess responses to vasoactive drugs. These measures were contrasted with a previous study examining male rats.
main outcome measuresOutcome measures used are gross anatomy, lumen diameter, wall thickness, cross-sectional area, and contractile responses in the internal pudendal artery.
resultsThe gross anatomy of the pudendal artery in female rats appears to parallel that found in male rats, acting as the primary feeder vessel of the clitoral, labial, and vaginal tissue. Compared with the male rat, the female pudendal artery has a smaller lumen diameter (169 ± 5.7 vs. 303 ± 13.8 µm), wall thickness (14 ± 0.7 vs. 47 ± 2.2 µm), and cross-sectional area (8 ± 0.4 vs. 52 ± 3.4 × 103 µm(2) ). These structural differences also translate into a decreased contractile capacity of the pudendal arteries from female rats vs. male rats (8.1 ± 2.7 vs. 20 ± 1.4 mN).
conclusionsAlthough the gross anatomical features of the vasculature tree supplying the genital tissue in male and female rats appear to have similarities, the tissue-specific properties of the vessel itself have a very different structure-function balance. We hypothesize that this discordance likely reflects the very different sex-specific roles of this vessel in regulating blood flow during arousal.
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