Evidence map›Paper›PMID 22023437›Full record

ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2012

Subjective social status predicts in vivo responsiveness of β-adrenergic receptors.

Frank Euteneuer, Paul J Mills, Winfried Rief, Michael G Ziegler, Joel E Dimsdale

Abstract read
In one paragraph

Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Is subjective social status a unique correlate of physical health? A meta-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017
    Pooled it
  2. Pooled it
  3. Article
  4. Subjective Social Status, Area Deprivation, and Gender Differences in Health among Chinese Older People.International journal of environmental research and public health · 2022
    Article
  5. Subjective Social Status and Cardiometabolic Risk Markers by Intersectionality of Race/Ethnicity and Sex Among U.S. Young Adults.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022
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  12. Neighborhood problems and nocturnal blood pressure dipping.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Frank EuteneuerDepartment of Psychiatry, University of California, San Diego, USA.
Paul J Mills
Winfried Rief
Michael G Ziegler
Joel E Dimsdale

Funding

SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
STRESS PHYSIOLOGY, DIETARY SALT, AND HYPERTENSIONR01HL036005 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIMSDALE, JOEL E · 1985 to 2010
$5.1M
SLEEP APNEA &HYPERTENSION--ROLE OF SYMP NERVOUS SYSTEMR01HL044915 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIMSDALE, JOEL E · 1991 to 2008
$4.7M
NCRR NIH HHS 1UL1RR031980NCRR NIH HHS UL1 RR031980NHLBI NIH HHS HL36005NHLBI NIH HHS HL44915NHLBI NIH HHS HL57269NHLBI NIH HHS R01 HL036005NHLBI NIH HHS R01 HL044915
6 · The paper itself

Abstract

objectiveSeveral poor health outcomes, including cardiovascular risk, have been associated with both subjective social status (SSS) and sympathetic overactivity. Because prolonged sympathetic overactivation down regulates beta adrenergic receptor (β-AR) function, reduced β-AR responsiveness is considered an indicator of sympathetic overactivity and a cardiovascular risk factor. Though prior research has focused on objective social status and β-AR function, no studies have examined the association between SSS and β-AR function. We aimed to learn whether SSS predicts the in vivo responsiveness of β-ARs.

methodsWe assessed the chronotropic 25 dose (CD25), an in vivo marker of β-AR responsiveness, in 94 healthy participants. The MacArthur scales of subjective social status were used to assess SSS in the U.S.A. (SSS-USA) and in the local community (SSS-C). Objective social status was analyzed by calculating the Hollingshead two-factor index.

resultsβ-AR responsiveness was reduced (as indicated by higher CD25 values) in participants with lower SSS-USA (p = .007) and lower SSS-C (p < .001). The relationship between CD25 and SSS was particularly robust with respect to SSS-C. Hierarchical regression analyses revealed that SSS-C remained a significant predictor of CD25 (p < .001) and accounted for 14% of the total variance (32%) in CD25 after adjusting for sociodemographic variables (age, ethnicity, gender), health factors (exercise, smoking status, body mass index) and objective social status.

conclusionOur results indicate that β-AR function may be an important component of the link between SSS and health.

Indexed as

Social ClassAdultBiomarkersBody Mass IndexCardiovascular DiseasesCardiovascular SystemEthnicityFemaleHealth StatusHeart RateHumansIsoproterenolMaleMiddle AgedReceptors, Adrenergic, betaRegression AnalysisBiomarkersIsoproterenolReceptors, Adrenergic, beta

Identifiers

PMID22023437
PMCPMC3386425

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.