Evidence map›Paper›PMID 22023238›Full record

ReviewOral diseases2012

New technologies for studying the complexity of oral diseases.

P D Burbelo, A Bayat, E E Lebovitz, M J Iadarola

Abstract readReview
In one paragraph

Review in Oral diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Direct assessment of the antioxidant property of salivary histatin.Journal of clinical biochemistry and nutrition · 2019
    Article
  7. Article
  8. Article
  9. Article
  10. The Proteomics of Saliva in Sjögren's Syndrome.Rheumatic diseases clinics of North America · 2016
    Review
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

P D BurbeloNeurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. burbelop@nidcr.nih.gov
A Bayat
E E Lebovitz
M J Iadarola

Funding

Mechanisms of Pain and Immune ProcessesZIADE000724 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI IADAROLA, MICHAEL J. · 2009 to 2012
$2.6M
Mechanisms of Pain and Immune ProcessesZIACL090034 · CLC · CLINICAL CENTER · PI MANNES, ANDREW · 2014 to 2025
$0k
Intramural NIH HHS Z99 DA999999Intramural NIH HHS Z99 DE999999Intramural NIH HHS Z99 OD999999
6 · The paper itself

Abstract

Several new technologies are providing useful diagnostic tools and new information related to the pathogenesis of certain oral diseases. In this review, we describe several of these technologies including gene and microRNA arrays, proteomics, and antigen arrays as they relate to the study of Sjögren's syndrome and head and neck cancer. A common theme is the systematic analysis of large-scale inventories of RNAs, proteins, and autoantibody biomarkers revealing information not previously recognized. We also discuss metagenomic approaches that characterize the many different microorganisms present in the oral cavity that may impact oral and human health. Lastly, we describe applications of a new type of antibody-profiling technology termed Luciferase Immunoprecipitation Systems (LIPS), which has a wide dynamic range of detection of both linear and conformational epitopes needed for optimum diagnostics and biomarker discovery. We propose that the information offered by these technologies will enhance our ability to diagnose, treat, and further understand the pathogenesis of multiple oral diseases.

Indexed as

Molecular Diagnostic TechniquesAntibodiesBiomarkersGene Expression ProfilingHead and Neck NeoplasmsHumansImmunoprecipitationLuciferasesMetagenomeMicroRNAsMouthSalivaSalivary Proteins and PeptidesSjogren's SyndromeAntibodiesBiomarkersLuciferasesMicroRNAsSalivary Proteins and Peptides

Identifiers

PMID22023238
PMCPMC3260408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.