ArticleThe Biochemical journal1990
Translocation of the brain-type glucose transporter largely accounts for insulin stimulation of glucose transport in BC3H-1 myocytes.
Article in The Biochemical journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 48 citations in OpenAlex.
- Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2.Frontiers in pharmacology · 2020Article
- α1A-Adrenergic receptor prevents cardiac ischemic damage through PKCδ/GLUT1/4-mediated glucose uptake.Journal of receptor and signal transduction research · 2016Article
- Islet transplantation under the kidney capsule fully corrects the impaired skeletal muscle glucose transport system of streptozocin diabetic rats.The Journal of clinical investigation · 1996Article
- Possible domains responsible for intracellular targeting and insulin-dependent translocation of glucose transporter type 4.The Biochemical journal · 1995Article
- Mechanisms and time course of impaired skeletal muscle glucose transport activity in streptozocin diabetic rats.The Journal of clinical investigation · 1995Article
- Regulation of the GLUT1 glucose transporter in cultured myocytes: total number and subcellular distribution as determined by photoaffinity labelling.The Biochemical journal · 1994Article
- Mitogen-activated protein kinase (MAP kinase), MAP kinase kinase and c-Mos stimulate glucose transport in Xenopus oocytes.The Biochemical journal · 1993Article
- Glucose transporters and in vivo glucose uptake in skeletal and cardiac muscle: fasting, insulin stimulation and immunoisolation studies of GLUT1 and GLUT4.The Biochemical journal · 1993Article
- Hormonal regulation of glucose transporters in muscle cells in culture.Journal of endocrinological investigation · 1993Review
- Glucose transport in human skeletal muscle cells in culture. Stimulation by insulin and metformin.The Journal of clinical investigation · 1992Article
- Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes.The Journal of clinical investigation · 1992Review
- Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.The Journal of cell biology · 1991Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Insulin-stimulated glucose transport was examined in BC3H-1 myocytes. Insulin treatment lead to a 2.7 +/- 0.3-fold increase in the rate of deoxyglucose transport and, under the same conditions, a 2.1 +/- 0.1-fold increase in the amount of the brain-type glucose transporter (GLUT 1) at the cell surface. It has been shown that some insulin-responsive tissues express a second, immunologically distinct, transporter, namely GLUT 4. We report here that BC3H-1 myocytes and C2 and G8 myotubes express only GLUT 1; in contrast, rat soleus muscle and heart express 3-4 times higher levels of GLUT 4 than GLUT 1. Thus translocation of GLUT 1 can account for most, if not all, of the insulin stimulation of glucose transport in BC3H-1 myocytes. On the other, hand, neither BC3H-1 myocytes nor the other muscle-cell lines are adequate as models for the study of insulin regulation of glucose transport in muscle tissue.
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