Evidence map›Paper›PMID 22022634›Full record

ArticleStatistics and its interface2011

Accurate and flexible power calculations on the spot: Applications to genomic research.

Hemant K Tiwari, Thomas Birkner, Ankur Moondan, Shiju Zhang, Grier P Page, Amit Patki, David B Allison

Abstract read
In one paragraph

Article in Statistics and its interface, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hemant K TiwariDepartment of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA, htiwari@uab.edu.
Thomas Birkner
Ankur Moondan
Shiju Zhang
Grier P Page
Amit Patki
David B Allison

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Gareth R Dutton · 2000 to 2026
$31.9M
Program Project in the Genetics of SLEP01AR049084 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2002 to 2012
$12.7M
The molecular genetic analysis of human obesityR01DK052431 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHUNG, WENDY K, LEIBEL, RUDOLPH L · 1996 to 2020
$11.6M
Genetics of Obesity in Yup'ik EskimosR01DK074842 · NIDDK · UNIVERSITY OF ALASKA FAIRBANKS · PI BOYER, BERT BRANDON · 2007 to 2011
$2.8M
UAB Biostatistics Pre-doctoral Training ProgramT32HL079888 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALLISON, DAVID B, CUTTER, GARY R · 2005 to 2014
$2.3M
Genome-wide Structured Association Testing & Regional Admixture MappingR01GM077490 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIU, NIANJUN · 2007 to 2010
$1.1M
Multiple Imputation in Genetic StudiesR21LM008791 · NLM · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TIWARI, HEMANT K. · 2007 to 2008
$280k
NHLBI NIH HHS T32 HL079888NIAMS NIH HHS P01 AR049084NIDDK NIH HHS P30 DK056336NIDDK NIH HHS R01 DK052431NIDDK NIH HHS R01 DK074842NIGMS NIH HHS R01 GM077490NLM NIH HHS R21 LM008791
6 · The paper itself

Abstract

Often investigators need to calculate power to demonstrate feasibility of proposed genetic studies for grant proposals or simply to aid in their own study planning. Frequently, power can be easily calculated using a closed form formula. However, in some situations such formulae for calculating power have not been derived and derivation on demand may be difficult if not impossible. In these situations investigators typically perform simulations specific to the study. Yet such simulations can be computationally extensive and take weeks to months depending on the circumstances. Here, we provide a simple method to rapidly estimate power when one has power estimates available for corresponding situations that differ from the situation of interest only in sample size and/or alpha (type I error) level desired. We show by application to multiple published results from the genomics field that these methods are generally very accurate and applicable to a broad range of genomic studies.

Identifiers

PMID22022634
PMCPMC3196559

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.