ArticlePloS one2011
Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Chromosome 1p status in neuroblastoma correlates with higher expression levels of miRNAs targeting neuronal differentiation pathway.In vitro cellular & developmental biology. Animal · 2023Article
- SHetA2 Attack on Mortalin and Colleagues in Cancer Therapy and Prevention.Frontiers in cell and developmental biology · 2022Review
- The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Withania somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells.Molecular neurobiology · 2016Article
- Stress chaperone mortalin regulates human melanogenesis.Cell stress & chaperones · 2016Article
- NPGPx (GPx7): a novel oxidative stress sensor/transmitter with multiple roles in redox homeostasis.American journal of translational research · 2016Review
- Tinospora cordifolia Induces Differentiation and Senescence Pathways in Neuroblastoma Cells.Molecular neurobiology · 2015Article
- Functional significance of point mutations in stress chaperone mortalin and their relevance to Parkinson disease.The Journal of biological chemistry · 2015Article
- Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation.PloS one · 2015Article
- Identification and functional characterization of nuclear mortalin in human carcinogenesis.The Journal of biological chemistry · 2014Article
- Retinoic acid inhibits the cytoproliferative response to weak 50‑Hz magnetic fields in neuroblastoma cells.Oncology reports · 2013Article
- Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update.Archives of toxicology · 2013Review
- Aqueous ethanolic extract of Tinospora cordifolia as a potential candidate for differentiation based therapy of glioblastomas.PloS one · 2013Article
- Withania somnifera water extract as a potential candidate for differentiation based therapy of human neuroblastomas.PloS one · 2013Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinoic acid (RA) has been approved for the differentiation therapy of neuroblastoma (NB). Previous work revealed a correlation between glucose-regulated protein 75 (GRP75) and the RA-elicited neuronal differentiation of NB cells. The present study further demonstrated that GRP75 translocates into the nucleus and physically interacts with retinoid receptors (RARα and RXRα) to augment RA-elicited neuronal differentiation. GRP75 was required for RARα/RXRα-mediated transcriptional regulation and was shown to reduce the proteasome-mediated degradation of RARα/RXRαin a RA-dependent manner. More intriguingly, the level of GRP75/RARα/RXRα tripartite complexes was tightly associated with the RA-induced suppression of tumor growth in animals and the histological grade of differentiation in human NB tumors. The formation of GRP75/RARα/RXRα complexes was intimately correlated with a normal MYCN copy number of NB tumors, possibly implicating a favorable prognosis of NB tumors. The present findings reveal a novel function of nucleus-localized GRP75 in actively promoting neuronal differentiation, delineating the mode of action for the differentiation therapy of NB by RA.
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