Evidence map›Paper›PMID 22022535›Full record

ArticlePloS one2011

Color capable sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis.

Seung Ah Lee, Ricardo Leitao, Guoan Zheng, Samuel Yang, Ana Rodriguez, Changhuei Yang

Abstract read
In one paragraph

Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Microfluidic Based Optical Microscopes on Chip.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2018
    Review
  10. Article
  11. Image analysis and machine learning for detecting malaria.Translational research : the journal of laboratory and clinical medicine · 2018
    Review
  12. Article
  13. Article
  14. Article
  15. Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seung Ah LeeDepartment of Electrical Engineering, California Institute of Technology, Pasadena, California, United States of America. salee30@caltech.edu
Ricardo Leitao
Guoan Zheng
Samuel Yang
Ana Rodriguez
Changhuei Yang

Funding

Multiplex fluorescence optofluidic microscopy for diagnosis of enteric parasitesR01AI096226 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI YANG, CHANGHUEI · 2011 to 2015
$5.8M
NIAID NIH HHS R01 AI096226
6 · The paper itself

Abstract

Miniaturization of imaging systems can significantly benefit clinical diagnosis in challenging environments, where access to physicians and good equipment can be limited. Sub-pixel resolving optofluidic microscope (SROFM) offers high-resolution imaging in the form of an on-chip device, with the combination of microfluidics and inexpensive CMOS image sensors. In this work, we report on the implementation of color SROFM prototypes with a demonstrated optical resolution of 0.66 µm at their highest acuity. We applied the prototypes to perform color imaging of red blood cells (RBCs) infected with Plasmodium falciparum, a particularly harmful type of malaria parasites and one of the major causes of death in the developing world.

Indexed as

ColorErythrocytesHumansMalariaMicrofluidicsMicroscopyPlasmodium falciparum

Identifiers

PMID22022535
PMCPMC3191177

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.