ArticlePloS one2011
Predictors of fatigue severity in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Moderating Effects of Clinical and Social Factors on Fatigue Improvement After an Online Peer-Led Fatigue Self-management Intervention in People With Systemic Sclerosis: A Secondary Analysis of a Randomized Controlled Trial.Archives of physical medicine and rehabilitation · 2025Trial
- Effects of a Resilience-Building Energy Management Program on Fatigue and Other Symptoms in Systemic Sclerosis: A Randomized Controlled Trial.Arthritis care & research · 2024Trial
- Tocilizumab Prevents Progression of Early Systemic Sclerosis-Associated Interstitial Lung Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2021Trial
- A distinct gastrointestinal symptom profile characterizes clinically relevant fatigue in systemic sclerosis.Clinical rheumatology · 2026Article
- 'It helps me stay on track': patient experiences using a mobile app for self-management of systemic sclerosis with a focus on fatigue in women.Rheumatology advances in practice · 2026Article
- Respiratory Manifestations and Their Physical, Psychological, and Social Impacts in Ehlers-Danlos Syndromes and Generalized Hypermobility Spectrum Disorders: A Narrative Review.Journal of clinical medicine · 2025Review
- Prevalence and Outcomes of Gastrointestinal Manifestations in an Australian Scleroderma Cohort.Arthritis care & research · 2024Article
- Within-person fluctuations of fatigue in patients with a clinical diagnosis of systemic sclerosis and its relationship with mood, pain, sleep and physical activity.Journal of scleroderma and related disorders · 2024Article
- Thyroid Disorders in Systemic Sclerosis: A Comprehensive Review.Journal of clinical medicine · 2024Review
- Systemic sclerosis.Lancet (London, England) · 2023Review
- Distinct molecular subtypes of systemic sclerosis and gene signature with diagnostic capability.Frontiers in immunology · 2023Article
- Minimal Clinically Important Differences (MCID) for the Functional Assessment of Chronic Illness Therapy Fatigue Scale in Patients with Systemic Sclerosis.International journal of environmental research and public health · 2022Article
- Article
- The association between hand disease severity and fatigue in individuals with systemic sclerosis: a scoping review.Disability and rehabilitation · 2022Article
- Fatigue and activity management education for individuals with systemic sclerosis: Adaptation and feasibility study of an intervention for a rare disease.Musculoskeletal care · 2022Article
- Autoantigen microarrays reveal myelin basic protein autoantibodies in morphea.Journal of translational medicine · 2022Article
- Fatigue Predicts Future Reduced Social Participation, not Reduced Physical Function or Quality of Life in People with Systemic Sclerosis.Journal of scleroderma and related disorders · 2021Article
- Fatigue and its relationship with disease-related factors in patients with systemic sclerosis: A cross-sectional studyTurkish journal of medical sciences · 2021Article
- Multi-Method Approach in the Assessment of Alexithymia in Patients With Scleroderma: Use of Two Different Tools.Frontiers in psychology · 2021Article
- Treatment of systemic sclerosis-associated interstitial lung disease: Lessons from clinical trials.Journal of scleroderma and related disorders · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesLongitudinal studies examining the baseline predictors of fatigue in SSc have not been reported. Our objectives were to examine the course of fatigue severity over time and to identify baseline clinical, demographic, and psychosocial predictors of sequentially obtained fatigue scores in early SSc. We also examined baseline predictors of change in fatigue severity over time.
methodsWe analyzed 1090 longitudinal Fatigue Severity Scale (FSS) scores belonging to 256 patients who were enrolled in the Genetics versus Environment in Scleroderma Outcomes Study (GENISOS). Predictive significance of baseline variables for sequentially obtained FSS scores was examined with generalized linear mixed models. Predictors of change in FSS over time were examined by adding an interaction term between the baseline variable and time-in-study to the model.
resultsThe patients' mean age was 48.6 years, 47% were Caucasians, and 59% had diffuse cutaneous involvement. The mean disease duration at enrollment was 2.5 years. The FSS was obtained at enrollment and follow-up visits (mean follow-up time = 3.8 years). Average baseline FSS score was 4.7(±0.96). The FSS was relatively stable and did not show a consistent trend for change over time (p = 0.221). In a multivariable model of objective clinical variables, higher Medsger Gastrointestinal (p = 0.006) and Joint (p = 0.024) Severity Indices, and anti-U1-RNP antibodies (p = 0.024) were independent predictors of higher FSS. In the final model, ineffective coping skills captured by higher Illness Behavior Questionnaire scores (p<0.001), higher self-reported pain (p = 0.006), and higher Medsger Gastrointestinal Severity Index (p = 0.009) at enrollment were independent predictors of higher longitudinal FSS scores. Baseline DLco % predicted was the only independent variable that significantly predicted a change in FSS scores over time (p = 0.013), with lower DLco levels predicting an increase in FSS over time.
conclusionsThis study identified potentially modifiable clinical and psychological factors that predict longitudinal fatigue severity in early SSc.
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