ArticlePloS one2011
Very few RNA and DNA sequence differences in the human transcriptome.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- General Principles and Limitations for Detection of RNA Modifications by Sequencing.Accounts of chemical research · 2024Article
- Venom phenotype conservation suggests integrated specialization in a lizard-eating snake.Toxicon : official journal of the International Society on Toxinology · 2023Article
- The landscape of coding RNA editing events in pediatric cancer.BMC cancer · 2021Article
- Article
- Repurposing RNA sequencing for discovery of RNA modifications in clinical cohorts.Science advances · 2021Article
- Pan-RNA editing analysis of the bovine genome.RNA biology · 2021Article
- Neoantigen prediction in human breast cancer using RNA sequencing data.Cancer science · 2021Article
- Naturally occurring modified ribonucleosides.Wiley interdisciplinary reviews. RNA · 2020Review
- Non-canonical RNA-DNA differences and other human genomic features are enriched within very short tandem repeats.PLoS computational biology · 2020Article
- CREDO: Highly confident disease-relevant A-to-I RNA-editing discovery in breast cancer.Scientific reports · 2019Article
- Single-nucleotide variants in human RNA: RNA editing and beyond.Briefings in functional genomics · 2019Review
- A-to-I RNA editing - immune protector and transcriptome diversifier.Nature reviews. Genetics · 2018Review
- Phenotypic Variation in Mojave Rattlesnake (Crotalus scutulatus) Venom Is Driven by Four Toxin Families.Toxins · 2018Article
- Adaptation of A-to-I RNA editing in Drosophila.PLoS genetics · 2017Article
- Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats.Molecular biology and evolution · 2016Article
- Identification of human RNA editing sites: A historical perspective.Methods (San Diego, Calif.) · 2016Review
- RES-Scanner: a software package for genome-wide identification of RNA-editing sites.GigaScience · 2016Article
- Article
- The Extent of mRNA Editing Is Limited in Chicken Liver and Adipose, but Impacted by Tissular Context, Genotype, Age, and Feeding as Exemplified with a Conserved Edited Site in COG3.G3 (Bethesda, Md.) · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
RNA editing is an important cellular process by which the nucleotides in a mature RNA transcript are altered to cause them to differ from the corresponding DNA sequence. While this process yields essential transcripts in humans and other organisms, it is believed to occur at a relatively small number of loci. The rarity of RNA editing has been challenged by a recent comparison of human RNA and DNA sequence data from 27 individuals, which revealed that over 10,000 human exonic sites appear to exhibit RNA-DNA differences (RDDs). Many of these differences could not have been caused by either of the two previously known human RNA editing mechanisms--ADAR-mediated A→G substitutions or APOBEC1-mediated C→U switches--suggesting that a previously unknown mechanism of RNA editing may be active in humans. Here, we reanalyze these data and demonstrate that genomic sequences exist in these same individuals or in the human genome that match the majority of RDDs. Our results suggest that the majority of these RDD events were observed due to accurate transcription of sequences paralogous to the apparently edited gene but differing at the edited site. In light of our results it seems prudent to conclude that if indeed an unknown mechanism is causing RDD events in humans, such events occur at a much lower frequency than originally proposed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.