ArticlePloS one2011
Microfluidic devices for analysis of spatial orientation behaviors in semi-restrained Caenorhabditis elegans.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- C. elegans foraging as a model for understanding the neuronal basis of decision-making.Cellular and molecular life sciences : CMLS · 2024Review
- The egg-counter: a novel microfluidic platform for characterization ofLab on a chip · 2024Article
- Microfluidic chip as a promising evaluation method in assisted reproduction: A systematic review.Bioengineering & translational medicine · 2024Review
- Microfluidic Localized Hydrogel Polymerization Enables Simultaneous Recording of Neural Activity and Behavior inReaction chemistry & engineering · 2024Article
- Neuronal sensorimotor integration guiding salt concentration navigation inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The nematode wormeLife · 2023Article
- Microfluidic-AssistedCyborg and bionic systems (Washington, D.C.) · 2023Article
- Making sense of sensory behaviors in vector-borne helminths.Trends in parasitology · 2022Review
- Article
- Corollary discharge promotes a sustained motor state in a neural circuit for navigation.eLife · 2021Article
- Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans.Scientific reports · 2019Article
- HowGenetics · 2019Review
- Microfluidic Devices Developed for and Inspired by Thermotaxis and Chemotaxis.Micromachines · 2018Review
- Experimental Evolution withGenetics · 2017Review
- Pneumatic stimulation of C. elegans mechanoreceptor neurons in a microfluidic trap.Lab on a chip · 2017Article
- Quantifying male and female pheromone-based mate choice in Caenorhabditis nematodes using a novel microfluidic technique.PloS one · 2017Article
- Microfluidic Devices in Advanced Caenorhabditis elegans Research.Molecules (Basel, Switzerland) · 2016Review
- Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans.Micromachines · 2016Review
- Temperature Sensing in Modular Microfluidic Architectures.Micromachines · 2016Article
- A mechanical microcompressor for high resolution imaging of motile specimens.Experimental cell research · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This article describes the fabrication and use of microfluidic devices for investigating spatial orientation behaviors in nematode worms (Caenorhabditis elegans). Until now, spatial orientation has been studied in freely moving nematodes in which the frequency and nature of encounters with the gradient are uncontrolled experimental variables. In the new devices, the nematode is held in place by a restraint that aligns the longitudinal axis of the body with the border between two laminar fluid streams, leaving the animal's head and tail free to move. The content of the fluid streams can be manipulated to deliver step gradients in space or time. We demonstrate the utility of the device by identifying previously uncharacterized aspects of the behavioral mechanisms underlying chemotaxis, osmotic avoidance, and thermotaxis in this organism. The new devices are readily adaptable to behavioral and imaging studies involving fluid borne stimuli in a wide range of sensory modalities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.