ArticlePloS one2011
Mainstreams of horizontal gene exchange in enterobacteria: consideration of the outbreak of enterohemorrhagic E. coli O104:H4 in Germany in 2011.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Genomic Islands Confer Heavy Metal Resistance inGenes · 2018Article
- Metabolic and evolutionary patterns in the extremely acidophilic archaeon Ferroplasma acidiphilum YScientific reports · 2017Article
- Genomic Analysis ofFrontiers in microbiology · 2017Article
- Evolution of a Heavy Metal Homeostasis/Resistance Island Reflects Increasing Copper Stress in Enterobacteria.Genome biology and evolution · 2016Article
- Pre_GI: a global map of ontological links between horizontally transferred genomic islands in bacterial and archaeal genomes.Database : the journal of biological databases and curation · 2015Article
- Classification of prokaryotic genetic replicators: between selfishness and altruism.Annals of the New York Academy of Sciences · 2015Article
- Microbiological Quality of Ready-to-Eat Vegetables Collected in Mexico City: Occurrence of Aerobic-Mesophilic Bacteria, Fecal Coliforms, and Potentially Pathogenic Nontuberculous Mycobacteria.BioMed research international · 2015Article
- Role of the horizontal gene exchange in evolution of pathogenic Mycobacteria.BMC evolutionary biology · 2015Article
- Analysis of genomic rearrangements, horizontal gene transfer and role of plasmids in the evolution of industrial important Thermus species.BMC genomics · 2014Article
- Towards a processual microbial ontology.Biology & philosophy · 2013Article
- Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica.Nature communications · 2013Article
- Evolutionary analyses of non-genealogical bonds produced by introgressive descent.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Antimicrobial-resistant Bacteria: An Unrecognized Work-related Risk in Food Animal Production.Safety and health at work · 2012Article
- Distribution of horizontally transferred heavy metal resistance operons in recent outbreak bacteria.Mobile genetic elements · 2012Article
- Vehicles, replicators, and intercellular movement of genetic information: evolutionary dissection of a bacterial cell.International journal of evolutionary biology · 2012Article
- Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEscherichia coli O104:H4 caused a severe outbreak in Europe in 2011. The strain TY-2482 sequenced from this outbreak allowed the discovery of its closest relatives but failed to resolve ways in which it originated and evolved. On account of the previous statement, may we expect similar upcoming outbreaks to occur recurrently or spontaneously in the future? The inability to answer these questions shows limitations of the current comparative and evolutionary genomics methods. PRINCIPAL
findingsThe study revealed oscillations of gene exchange in enterobacteria, which originated from marine γ-Proteobacteria. These mobile genetic elements have become recombination hotspots and effective 'vehicles' ensuring a wide distribution of successful combinations of fitness and virulence genes among enterobacteria. Two remarkable peculiarities of the strain TY-2482 and its relatives were observed: i) retaining the genetic primitiveness by these strains as they somehow avoided the main fluxes of horizontal gene transfer which effectively penetrated other enetrobacteria; ii) acquisition of antibiotic resistance genes in a plasmid genomic island of β-Proteobacteria origin which ontologically is unrelated to the predominant genomic islands of enterobacteria.
conclusionsOscillations of horizontal gene exchange activity were reported which result from a counterbalance between the acquired resistance of bacteria towards existing mobile vectors and the generation of new vectors in the environmental microflora. We hypothesized that TY-2482 may originate from a genetically primitive lineage of E. coli that has evolved in confined geographical areas and brought by human migration or cattle trade onto an intersection of several independent streams of horizontal gene exchange. Development of a system for monitoring the new and most active gene exchange events was proposed.
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