ArticleFrontiers in microbiology2011
Functional metagenomic investigations of the human intestinal microbiota.
Article in Frontiers in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility.Scientific reports · 2023Pooled it
- Gut microbiome dynamics in acute infectious diarrhea: A conceptual framework from acute dysbiosis toward precision restoration (Review).Experimental and therapeutic medicine · 2026Review
- Integrated transcriptomic and microbiota analyses reveal growth-related intestinal responses to feeding strategies in Nibea coibor.Advanced biotechnology · 2025Article
- ResFinderFG v2.0: a database of antibiotic resistance genes obtained by functional metagenomics.Nucleic acids research · 2023Article
- Antibiotic-induced alternations in gut microflora are associated with the suppression of immune-related pathways in grass carp (Frontiers in immunology · 2022Article
- Metagenomic Screening for Lipolytic Genes Reveals an Ecology-Clustered Distribution Pattern.Frontiers in microbiology · 2022Article
- Potential Use of Gut Microbiota Composition as a Biomarker of Heat Stress in Monogastric Species: A Review.Animals : an open access journal from MDPI · 2021Review
- Experimental approaches to tracking mobile genetic elements in microbial communities.FEMS microbiology reviews · 2020Review
- Could the gut microbiota community in the coral trout Plectropomus leopardus (Lacepède, 1802) be affected by antibiotic bath administration?Veterinary medicine and science · 2020Article
- Insights into microbial community structure and diversity in oil palm waste compost.3 Biotech · 2019Article
- Clinical Resistome Screening of 1,110Frontiers in microbiology · 2019Article
- Prediction of antibiotic resistance: time for a new preclinical paradigm?Nature reviews. Microbiology · 2017Review
- The Bacteroidales produce an N-acylated derivative of glycine with both cholesterol-solubilising and hemolytic activity.Scientific reports · 2017Article
- Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes.Annals of the New York Academy of Sciences · 2017Review
- Translational metagenomics and the human resistome: confronting the menace of the new millennium.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Assessing the Intestinal Microbiota in the SHINE Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- The intestinal microbiome of fish under starvation.BMC genomics · 2014Article
- Experimental approaches for defining functional roles of microbes in the human gut.Annual review of microbiology · 2013Review
- Host-microbe interactions in the neonatal intestine: role of human milk oligosaccharides.Advances in nutrition (Bethesda, Md.) · 2012Review
- Human health and disease in a microbial world.Frontiers in microbiology · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human intestinal microbiota encode multiple critical functions impacting human health, including metabolism of dietary substrate, prevention of pathogen invasion, immune system modulation, and provision of a reservoir of antibiotic resistance genes accessible to pathogens. The complexity of this microbial community, its recalcitrance to standard cultivation, and the immense diversity of its encoded genes has necessitated the development of novel molecular, microbiological, and genomic tools. Functional metagenomics is one such culture-independent technique, used for decades to study environmental microorganisms, but relatively recently applied to the study of the human commensal microbiota. Metagenomic functional screens characterize the functional capacity of a microbial community, independent of identity to known genes, by subjecting the metagenome to functional assays in a genetically tractable host. Here we highlight recent work applying this technique to study the functional diversity of the intestinal microbiota, and discuss how an approach combining high-throughput sequencing, cultivation, and metagenomic functional screens can improve our understanding of interactions between this complex community and its human host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.