Evidence map›Paper›PMID 22022309›Full record

ArticleFrontiers in integrative neuroscience2011

Unwinding the molecular basis of interval and circadian timing.

Patricia V Agostino, Diego A Golombek, Warren H Meck

Abstract read
In one paragraph

Article in Frontiers in integrative neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Role of the Serotonergic System in Time Perception: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Circadian Dysregulation in Parkinson's Disease.Neurobiology of sleep and circadian rhythms · 2017
    Article
  11. Emotional modulation of interval timing and time perception.Neuroscience and biobehavioral reviews · 2016
    Review
  12. Review
  13. Article
  14. Article
  15. Time perception: the bad news and the good.Wiley interdisciplinary reviews. Cognitive science · 2014
    Review
  16. Article
  17. Towards an integrated understanding of the biology of timing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Patricia V AgostinoLaboratorio de Cronobiología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes Buenos Aires, Argentina.
Diego A Golombek
Warren H Meck

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural timing mechanisms range from the millisecond to diurnal, and possibly annual, frequencies. Two of the main processes under study are the interval timer (seconds-to-minute range) and the circadian clock. The molecular basis of these two mechanisms is the subject of intense research, as well as their possible relationship. This article summarizes data from studies investigating a possible interaction between interval and circadian timing and reviews the molecular basis of both mechanisms, including the discussion of the contribution from studies of genetically modified animal models. While there is currently no common neurochemical substrate for timing mechanisms in the brain, circadian modulation of interval timing suggests an interaction of different frequencies in cerebral temporal processes.

Indexed as

circadian systemcortico-striatal circuitsdopamineglutamateinterval timingserotoninsuprachiasmatic nuclei

Identifiers

PMID22022309
PMCPMC3196210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.