ArticlePLoS genetics2011
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Transethnic meta-analysis of exome-wide variants identifies new loci associated with male-specific metabolic syndrome.Genes & genomics · 2022Pooled it
- Genome-Wide Association Analyses of Equine Metabolic Syndrome Phenotypes in Welsh Ponies and Morgan Horses.Genes · 2019Pooled it
- Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study.Circulation. Cardiovascular genetics · 2014Pooled it
- Large deletions in the DNA primase large subunit PRIM2 are associated with NADP-malate dehydrogenase activity in a porcine FAnimal genetics · 2026Article
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- Integrative DNA methylation and transcriptome analysis reveal cell-type specific patterns in response to elevated allostatic load.Epigenetics · 2025Article
- Genome-wide association analysis of composite sleep health scores in 413,904 individuals.Communications biology · 2025Article
- Age effect on the shared etiology of glycemic traits and serum lipids: evidence from a Chinese twin study.Journal of endocrinological investigation · 2024Article
- Statistical Inference for High-Dimensional Pathway Analysis with Multiple Responses.Computational statistics & data analysis · 2022Article
- Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case-control study in the Tunisian population and a meta-analysis.Diabetology & metabolic syndrome · 2022Article
- Mapping pleiotropic loci using a fast-sequential testing algorithm.European journal of human genetics : EJHG · 2021Article
- Multi-phenotype genome-wide association studies of the Norfolk Island isolate implicate pleiotropic loci involved in chronic kidney disease.Scientific reports · 2021Article
- Comparison of adaptive multiple phenotype association tests using summary statistics in genome-wide association studies.Human molecular genetics · 2021Article
- Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power.Nature genetics · 2021Article
- Understanding the genetic architecture of the metabolically unhealthy normal weight and metabolically healthy obese phenotypes in a Korean population.Scientific reports · 2021Article
- Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases.Genome medicine · 2020Article
- An epigenome-wide association study of metabolic syndrome and its components.Scientific reports · 2020Article
- CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption.Scientific reports · 2020Article
- Multi-Ethnic Genome-Wide Association Study of Decomposed Cardioelectric Phenotypes Illustrates Strategies to Identify and Characterize Evidence of Shared Genetic Effects for Complex Traits.Circulation. Genomic and precision medicine · 2020Article
- A phenomics-based approach for the detection and interpretation of shared genetic influences on 29 biochemical indices in southern Chinese men.BMC genomics · 2019Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors.
Funding
Abstract
Despite evidence of the clustering of metabolic syndrome components, current approaches for identifying unifying genetic mechanisms typically evaluate clinical categories that do not provide adequate etiological information. Here, we used data from 19,486 European American and 6,287 African American Candidate Gene Association Resource Consortium participants to identify loci associated with the clustering of metabolic phenotypes. Six phenotype domains (atherogenic dyslipidemia, vascular dysfunction, vascular inflammation, pro-thrombotic state, central obesity, and elevated plasma glucose) encompassing 19 quantitative traits were examined. Principal components analysis was used to reduce the dimension of each domain such that >55% of the trait variance was represented within each domain. We then applied a statistically efficient and computational feasible multivariate approach that related eight principal components from the six domains to 250,000 imputed SNPs using an additive genetic model and including demographic covariates. In European Americans, we identified 606 genome-wide significant SNPs representing 19 loci. Many of these loci were associated with only one trait domain, were consistent with results in African Americans, and overlapped with published findings, for instance central obesity and FTO. However, our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains. These pleiotropic loci may help characterize metabolic dysregulation and identify targets for intervention.
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