ArticlePLoS genetics2011
Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 244 papers.
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Who cites it
244 citing papers in PubMed.
- Towards a Standard Threshold for Genome Wide Significance in Dogs.Animal genetics · 2026Article
- Genomic characterization of an Apennine heeling dog population: insights into diversity and conservation.Veterinary and animal science · 2026Article
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- Individualized circulating tumor DNA monitoring in two dogs with malignant melanoma.The Journal of veterinary medical science · 2026Article
- Image feature embedding with a deep learning framework improves genome-wide association studies on dog endophenotypes.Science advances · 2026Article
- An analysis of the genomic architecture of the worldwide Irish Wolfhound dogs.Scientific reports · 2026Article
- An interpretable machine learning framework for dog breed inference and ancestry decomposition.bioRxiv : the preprint server for biology · 2026Article
- Blood biomarkers and breed genetics of aging in pet dogs.bioRxiv : the preprint server for biology · 2026Article
- Genomic history of early dogs in Europe.Nature · 2026Article
- Identification of genetic variants associated with ear length in drop-eared dogs.Scientific reports · 2025Article
- Genomic ancestry, behavior, and the domestication of the dog.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetic testing predicts appearance but not behavior in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Genomic Exploration of the Possible De-Extirpation of the Zanzibar Leopard.Molecular ecology · 2025Article
- Integrative Genotyping and Analysis of Canine Structural Variation Using Long-read and Short-read Data.Genome biology and evolution · 2025Article
- Genotypic and phenotypic consequences of domestication in dogs.bioRxiv : the preprint server for biology · 2025Article
- Comparing owner reported and genetic breed identification reveals high concordance in a large cohort from the Dog Aging Project.Scientific reports · 2025Article
- Natural Born Detourers Modern Utility Dog Breeds Show Ancestry-Based Superiority in Social Learning Capacity in a Detour Task.Evolutionary applications · 2025Article
- Characterizing differences in the muscle transcriptome between cattle with alternative LCORL-NCAPG haplotypes.BMC genomics · 2025Article
- Analysis of canine gene constraint identifies new variants for orofacial clefts and stature.Genome research · 2025Article
184 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors.
Funding
Abstract
The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits. Here we perform a comprehensive analysis using multiple test statistics to identify regions under selection in 509 dogs from 46 diverse breeds using a newly developed high-density genotyping array consisting of >170,000 evenly spaced SNPs. We first identify 44 genomic regions exhibiting extreme differentiation across multiple breeds. Genetic variation in these regions correlates with variation in several phenotypic traits that vary between breeds, and we identify novel associations with both morphological and behavioral traits. We next scan the genome for signatures of selective sweeps in single breeds, characterized by long regions of reduced heterozygosity and fixation of extended haplotypes. These scans identify hundreds of regions, including 22 blocks of homozygosity longer than one megabase in certain breeds. Candidate selection loci are strongly enriched for developmental genes. We chose one highly differentiated region, associated with body size and ear morphology, and characterized it using high-throughput sequencing to provide a list of variants that may directly affect these traits. This study provides a catalogue of genomic regions showing extreme reduction in genetic variation or population differentiation in dogs, including many linked to phenotypic variation. The many blocks of reduced haplotype diversity observed across the genome in dog breeds are the result of both selection and genetic drift, but extended blocks of homozygosity on a megabase scale appear to be best explained by selection. Further elucidation of the variants under selection will help to uncover the genetic basis of complex traits and disease.
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