ArticleBMJ open2011
UK stroke incidence, mortality and cardiovascular risk management 1999-2008: time-trend analysis from the General Practice Research Database.
Article in BMJ open, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Acupuncture for vascular mild cognitive impairment: an updated systematic review and meta-analysis of randomized controlled trials.Systematic reviews · 2026Pooled it
- Stroke risk after varicella-zoster virus infection: a systematic review and meta-analysis.Journal of neurovirology · 2023Pooled it
- Diverging Temporal Trends in Stroke Incidence in Younger vs Older People: A Systematic Review and Meta-analysis.JAMA neurology · 2022Pooled it
- Survival of patients with chronic heart failure in the community: a systematic review and meta-analysis.European journal of heart failure · 2019Pooled it
- Post-war (1946-2017) population health change in the United Kingdom: A systematic review.PloS one · 2019Pooled it
- Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis.BMJ (Clinical research ed.) · 2017Pooled it
- Systematic voiding programme in adults with urinary incontinence following acute stroke: the ICONS-II RCT.Health technology assessment (Winchester, England) · 2022Trial
- An extended stroke rehabilitation service for people who have had a stroke: the EXTRAS RCT.Health technology assessment (Winchester, England) · 2020Trial
- A randomised trial of social support group intervention for people with aphasia: A Novel application of virtual reality.PloS one · 2020Trial
- Long-term trends in the prevalence of patients hospitalized with ischemic stroke from 1995 to 2010 in Sweden.PloS one · 2017Trial
- Cost-effectiveness analysis of different systolic blood pressure targets for people with a history of stroke or transient ischaemic attack: Economic analysis of the PAST-BP study.European journal of preventive cardiology · 2016Trial
- Evaluating the Benefits of Aphasia Intervention Delivered in Virtual Reality: Results of a Quasi-Randomised Study.PloS one · 2016Trial
- Trial
- Trial
- The Effect of Age on Post-Stroke Language Outcomes.Journal of aging research · 2026Article
- Target the Heart: A New Axis of Alzheimer's Disease Prevention.Journal of dementia and alzheimer's disease · 2025Article
- Inhibiting CaNature neuroscience · 2024Article
- IMPACT CKD: Holistic Disease Model Projecting 10-Year Population Burdens.Kidney international reports · 2024Article
- Is the socioeconomic inequality in stroke prognosis changing over time and does quality of care play a role?European stroke journal · 2023Article
- Pre- and post-stroke oral antithrombotics and mortality in patients with ischaemic stroke.Pharmacoepidemiology and drug safety · 2022Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesStroke is a major cause of morbidity and mortality. This study aimed to investigate secular trends in stroke across the UK.
designThis study aimed to investigate recent trends in the epidemiology of stroke in the UK. The study was a time-trend analysis from 1999 to 2008 within the UK General Practice Research Database. Outcome measures were incidence and prevalence of stroke, stroke mortality, rate of secondary cardiovascular events, and prescribing of pharmacological therapy for primary and secondary prevention of cardiovascular disease.
resultsThe study cohort included 32,151 patients with a first stroke. Stroke incidence fell by 30%, from 1.48/1000 person-years in 1999 to 1.04/1000 person-years in 2008 (p<0.001). Stroke prevalence increased by 12.5%, from 6.40/1000 in 1999 to 7.20/1000 in 2008 (p<0.001). 56-day mortality after first stroke reduced from 21% in 1999 to 12% in 2008 (p<0.0001). Prescribing of drugs to control cardiovascular risk factors increased consistently over the study period, particularly for lipid lowering agents and antihypertensive agents. In patients with atrial fibrillation, use of anticoagulants prior to first stroke did not increase with increasing stroke risk.
conclusionStroke incidence in the UK has decreased and survival after stroke has improved in the past 10 years. Improved drug treatment in primary care is likely to be a major contributor to this, with better control of risk factors both before and after incident stroke. There is, however, scope for further improvement in risk factor reduction in high-risk patients with atrial fibrillation.
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