ArticleBMJ open2011
Effects of statin medication on mortality risk associated with type 2 diabetes in older persons: the population-based AGES-Reykjavik Study.
Article in BMJ open, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Association of statin use in older people primary prevention group with risk of cardiovascular events and mortality: a systematic review and meta-analysis of observational studies.BMC medicine · 2021 · on this mapPooled it
- Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2019Guideline
- Primary prevention of major cardiovascular and cerebrovascular events with statins in diabetic patients: a meta-analysis.Drugs · 2012 · on this mapPooled it
- Cardiovascular outcomes and safety associated with statin therapy for primary prevention in older adults with type 2 diabetes: A target trial emulation study.PLoS medicine · 2026Article
- Decrease in low-density lipoprotein cholesterol is associated with an increased risk of mortality in patients with diabetes mellitus.Frontiers in cardiovascular medicine · 2025Article
- Guideline for the Management of Diabetes Mellitus in the Elderly in China (2024 Edition).Aging medicine (Milton (N.S.W)) · 2024Article
- Review
- Effect of statin treatment on mortality in elderly patients with type 2 diabetes mellitus patients: a retrospective cohort study.BMC geriatrics · 2023Article
- Effects of Statin Dose, Class, and Use Intensity on All-Cause Mortality in Patients with Type 2 Diabetes Mellitus.Pharmaceuticals (Basel, Switzerland) · 2023Article
- In-Hospital Mortality and Its Predictors among Hospitalized Diabetes Patients: A Prospective Observational Study.International journal of clinical practice · 2023Observational
- Cholesterol and Phosphoinositides in Cilia Biology.Advances in experimental medicine and biology · 2023Review
- Statin use in older people primary prevention on cardiovascular disease: an updated systematic review and meta-analysis.Reviews in cardiovascular medicine · 2022Article
- Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study.BMJ (Clinical research ed.) · 2018Article
- Prevalence and determinants of carotid plaque in the cross-sectional REFINE-Reykjavik study.BMJ open · 2016Article
- Higher Plasma Phospholipid n-3 PUFAs, but Lower n-6 PUFAs, Are Associated with Lower Pulse Wave Velocity among Older Adults.The Journal of nutrition · 2015Article
- Carotid atherosclerosis and cardiovascular health metrics in old subjects from the AGES-Reykjavik study.Atherosclerosis · 2015Article
- Risk Factors Associated With Incident Cerebral Microbleeds According to Location in Older People: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study.JAMA neurology · 2015Article
- Statin Treatment and Mortality in Community-Dwelling Frail Older Patients with Diabetes Mellitus: A Retrospective Observational Study.PloS one · 2015Observational
- Declines in coronary heart disease incidence and mortality among middle-aged adults with and without diabetes.Annals of epidemiology · 2014Article
- Epidemiological studies of CHD and the evolution of preventive cardiology.Nature reviews. Cardiology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo examine if the beneficial effect of statin medication on mortality seen in randomised clinical trials of type 2 diabetes applies equally to observational studies in the general population of older people.
designA prospective, population-based cohort study.
settingReykjavik, Iceland.
participants5152 men and women from the Age, Gene/Environment Susceptibility-Reykjavik Study, mean age 77 years, range of 66-96 years.
main outcome measureCardiovascular and all-cause mortalities and the RR of dying according to statin use and history of coronary heart disease (CHD) in persons with type 2 diabetes and those without diabetes with a median follow-up time of 5.3 years, until end of 2009.
resultsThe prevalence of type 2 diabetes was 12.4% of which 35% used statins. Statin use was associated with a 50% (95% CI 8% to 72%) lower cardiovascular mortality and 53% (29% to 68%) lower all-cause mortalities in persons with diabetes. For those without diabetes, statin use was associated with a 16% (-24% to 43%) lower cardiovascular and 30% (11% to 46%) lower all-cause mortalities. Persons with diabetes using statins had a comparable risk of cardiovascular and all-cause mortality to that of the general population without diabetes. The effect was independent of the level of glycaemic control.
conclusionThis observational study lends important support to existing data from randomised clinical trials. These data suggest that in the general population of older people with diabetes, statin medication markedly reduces the excess cardiovascular and all-cause mortality risk, irrespective of the presence or absence of coronary heart disease or glucose-lowering medication.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.