ArticleBMJ open2011
Changes in somatic disease incidents during opioid maintenance treatment: results from a Norwegian cohort study.
Article in BMJ open, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03678792 (Time to Detox), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Time to Detox: A Patient-Centered Comparison of Length of Detoxification Treatment and Time to Naltrexone Maintenance Therapy in Opioid-Dependent Individuals
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Effectiveness of Injectable Extended-Release Naltrexone vs Daily Buprenorphine-Naloxone for Opioid Dependence: A Randomized Clinical Noninferiority Trial.JAMA psychiatry · 2017Trial
- Design of a randomized controlled trial of extended-release naltrexone versus daily buprenorphine-naloxone for opioid dependence in Norway (NTX-SBX).BMC pharmacology & toxicology · 2016Trial
- Unemployment & opioid use disorder - socio-medical assessment results by the Medical Service of the German Federal Employment Agency.Substance abuse treatment, prevention, and policy · 2026Article
- The Interaction Between Mental Distress and Opioid Maintenance Treatment Impacts Levels of Circulating Cytokines.Addiction biology · 2026Article
- Comparison of mortality and causes of death between treatment-engaged individuals with severe alcohol or opioid use disorder: a prospective 19-year clinical cohort study.BMC psychiatry · 2026Observational
- Universal Health Coverage of Opioid Agonist Treatment in Norway: An Equity-Adjusted Economic Evaluation.PharmacoEconomics · 2025Article
- Change in substance use among patients in opioid maintenance treatment: baseline to 1-year follow-up.Harm reduction journal · 2024Article
- Change in self-reported somatic symptoms among patients in opioid maintenance treatment from baseline to 1-year follow-up.BMC psychiatry · 2024Article
- Gender differences in physical morbidity in opioid agonist treatment patients: population-based cohort studies from the Czech Republic and Norway.Substance abuse treatment, prevention, and policy · 2023Article
- Mortality, Causes of Death, and Predictors of Death among Patients On and Off Opioid Agonist Treatment: Results from a 19-Year Cohort Study.European addiction research · 2022Article
- Too much or too little opioids to patients receiving opioid agonist therapy in Norway (2013-2017): a prospective cohort study.BMC health services research · 2020Article
- Mortality and causes of death among patients with opioid use disorder receiving opioid agonist treatment: a national register study.BMC health services research · 2019Observational
- Polluting pharmaceutical atmospheres: Compulsion, resistance, and symbolism of buprenorphine in Norway.Nordisk alkohol- & narkotikatidskrift : NAT · 2019Article
- Mortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort study.BMC psychiatry · 2019Article
- Stuck in limbo: illicit drug users' experiences with opioid maintenance treatment and the relation to recovery.International journal of qualitative studies on health and well-being · 2016Article
- Factors associated with involuntary admissions among patients with substance use disorders and comorbidity: a cross-sectional study.BMC health services research · 2013Article
- Somatic Comorbidity and Other Factors Related to Suicide Attempt Among Polish Methadone Maintenance Patients.Journal of addiction medicineArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives To examine the effect of opioid maintenance treatment (OMT) on somatic morbidity in a cohort of OMT patients. Design Retrospective cohort study. Setting OMT programme in two Norwegian counties. Participants 200 OMT patients, participation rate 71.2%. Main outcome measures Incidence rates (IR) before, during and after OMT for acute/subacute hospital-treated somatic disease incidents (drug-related, non-drug-related, injuries) and rates for inpatient days and outpatient treatment contacts. Results IR for drug-related hospital treatment episodes were 76% lower during compared to before OMT (before versus during incidence rate ratio (IRR) 4.2 (95% CI 2.9 to 6.2), p<0.001) and 11 times higher after compared to during OMT (after versus during IRR 11.1 (6.6 to 18.5), p<0.001). For non-drug-related treatment episodes, IR were 35% higher during than before OMT (before versus during IRR 0.7 (0.6 to 1.0), p=0.02) and 32% higher after compared to during OMT (IRR 1.4 (0.9 to 2.2), p=0.15), while injuries showed little change according to OMT status. Although patients with on-going drug-taking during OMT showed less reduction in drug-related hospital-treated incidents during treatment than patients not using illicit drugs, the quartile with most drug-taking showed a significant reduction (before versus during IRR 3.6 (2.4 to 5.3)). Patients who had experienced cessation of OMT showed a significant reduction in drug-related treatment episodes during OMT (before versus during IRR 1.7 (1.0 to 2.9)), although less than patients without OMT interruptions (before versus during IRR 6.1 (3.6 to 10.6)), and a significant increase after OMT cessation compared with during OMT (IRR 5.4 (3.0 to 9.7)). Conclusion Acute/subacute drug-related somatic morbidity is reduced during compared to before OMT. This was also found for patients with on-going drug-taking during OMT. However, acute drug-related health problems show an increase after OMT cessation, and this is a matter of concern. Further studies on somatic morbidity after OMT cessation should be carried out.
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Registered trials
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