ArticleBMJ open2011
A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study.
Article in BMJ open, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Associations of filaggrin gene loss-of-function variants and human papillomavirus-related cancer and pre-cancer in Danish adults.PloS one · 2014Trial
- Association Between Atopic Dermatitis and Aging: Clinical Observations and Underlying Mechanisms.Journal of inflammation research · 2024Review
- Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls.JID innovations : skin science from molecules to population health · 2023Article
- Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes.BMC medical genomics · 2023Article
- [Atopic dermatitis and general medical comorbidities].Der Internist · 2019Review
- BLT2 expression improves skin integrity and protects from alterations caused by hyperglycemia in type 2 diabetes.Dermato-endocrinology · 2017Article
- Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma.Current dermatology reports · 2017Review
- Skin disorders in diabetes mellitus: an epidemiology and physiopathology review.Diabetology & metabolic syndrome · 2016Review
- Heavy Cigarette Smokers in a Chinese Population Display a Compromised Permeability Barrier.BioMed research international · 2016Article
- Prospective population-based study of the association between vitamin D status and incidence of autoimmune disease.Endocrine · 2015Article
- Cause-specific mortality according to urine albumin creatinine ratio in the general population.PloS one · 2014Article
- Ichthyosis vulgaris: the filaggrin mutation disease.The British journal of dermatology · 2013Review
- Vitamin D status, filaggrin genotype, and cardiovascular risk factors: a Mendelian randomization approach.PloS one · 2013Article
- No association between loss-of-function mutations in filaggrin and diabetes, cardiovascular disease, and all-cause mortality.PloS one · 2013Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Filaggrin proteins are located in the skin and prevent epidermal water loss and impede the entry of micro-organisms, allergens and chemicals. Filaggrin null mutations are strongly associated with ichthyosis vulgaris and atopic dermatitis. Objective The authors aimed to investigate the association between filaggrin null mutations, atopic dermatitis and diabetes. Design A random sample of 3335 adults from the general population in Denmark was filaggrin-genotyped for R501X and 2282del4 null-mutations and questioned about atopic dermatitis and diabetes. Furthermore, two independent study populations of patients with type 1 (n=104) or 2 (n=774) diabetes were genotyped. Results In a crude data analysis, a positive association was detected between the filaggrin null genotype and, respectively, subjects from the general population who reported diabetes (p=0.04) and patients with established type 2 diabetes (p=0.073). Adjustment for age and gender resulted in significant associations for patients with type 2 diabetes (p=0.048) and subjects with self-reported diabetes (p=0.032). Conclusions Adult Danes with a filaggrin null genotype had a significantly increased prevalence of self-reported diabetes. This finding was replicated when an independent sample of Danish patients with established type 2 diabetes was compared with control subjects from the general population.
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