ArticleJournal of the American Society of Nephrology : JASN2011
Inflammation and the paradox of racial differences in dialysis survival.
Article in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients.Journal of the American Society of Nephrology : JASN · 2017Trial
- Cardiovascular Disease in CKD: Ethnic and Regional Differences in Risk and Phenotype.Clinical journal of the American Society of Nephrology : CJASN · 2026Review
- Using machine-learning to identify differences in the association between blood-based biomarkers and later life health across race and ethnicity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- A comprehensive exploration of chronic kidney disease and dialysis in Canada's Indigenous population: from epidemiology to genetic influences.International urology and nephrology · 2024Review
- Cardiovascular Disease in Chronic Kidney Disease: Implications of Cardiorespiratory Fitness, Race, and Sex.Reviews in cardiovascular medicine · 2024Review
- Association between the systemic inflammatory response index and mortality in patients with sarcopenia.PloS one · 2024Article
- Waiting-List and early posttransplant prognosis among ethnoracial groups: Data from the organ procurement and transplantation network.Frontiers in surgery · 2023Article
- The Effects of Race on Acute Kidney Injury.Journal of clinical medicine · 2022Review
- Race, Interleukin-6,Journal of the American Heart Association · 2022Article
- Race, Biomarkers, and Cardiovascular Disease in Patients With Chronic Kidney Disease.Journal of the American Heart Association · 2022Article
- Physical Resilience Phenotype Trajectories in Incident Hemodialysis: Characterization and Mortality Risk Assessment.Kidney international reports · 2022Article
- COVID-19 Risk Factors and Mortality Outcomes Among Medicare Patients Receiving Long-term Dialysis.JAMA network open · 2021Article
- Race and Mortality in CKD and Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020Article
- Racial differences in inflammation and outcomes of aging among kidney transplant candidates.BMC nephrology · 2019Article
- High Serum Alkaline Phosphatase, Hypercalcaemia, Race, and Mortality in South African Maintenance Haemodialysis Patients.International journal of nephrology · 2017Article
- Social Determinants of Racial Disparities in CKD.Journal of the American Society of Nephrology : JASN · 2016Review
- Risk Adjustment and the Assessment of Disparities in Dialysis Mortality Outcomes.Journal of the American Society of Nephrology : JASN · 2015Article
- Neutrophil/lymphocyte ratio as a predictor of cardiovascular events in incident dialysis patients: a Japanese prospective cohort study.Clinical and experimental nephrology · 2015Article
- Aging and low-grade inflammation reduce renal function in middle-aged and older adults in Japan and the USA.Age (Dordrecht, Netherlands) · 2015Article
- Race, Mineral Homeostasis and Mortality in Patients with End-Stage Renal Disease on Dialysis.American journal of nephrology · 2015Article
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5 authors at 4 institutions in 1 country.
Funding
Abstract
African Americans experience a higher mortality rate and an excess burden of ESRD compared with Caucasians in the general population, but among those treated with dialysis, African Americans typically survive longer than Caucasians. We examined whether differences in inflammation may explain this paradox. We prospectively followed a national cohort of incident dialysis patients in 81 clinics for a median of 3 years (range 4 months to 9.5 years). Among 554 Caucasians and 262 African Americans, we did not detect a significant difference in median CRP between African Americans and Caucasians (3.4 versus 3.9 mg/L). Mortality was significantly lower for African Americans versus Caucasians (34% versus 56% at 5 years); the relative hazard was 0.7 (95% CI, 0.5 to 0.9) after adjusting for age, gender, dialysis modality, smoking, body mass index, diabetes, BP, cholesterol, cardiovascular disease, congestive heart failure, comorbid disease, hemoglobin, albumin, CRP, and IL-6. However, the risk varied by CRP tertile: the relative hazards for African Americans compared with Caucasians were 1.0 (95% CI, 0.7 to 1.4), 0.7 (95% CI, 0.4 to 1.3), and 0.5 (95% CI, 0.3 to 0.8) in the lowest, middle, and highest tertiles, respectively. We obtained similar results when we accounted for transplantation as a competing event, and we examined mortality across tertiles of IL-6. In summary, racial differences in survival among dialysis patients are not present at low levels of inflammation but are large at higher levels. Differences in inflammation may explain, in part, the racial paradox of ESRD survival.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.