ArticleJournal of the American Society of Nephrology : JASN2011
Characterization and fate of telomerase-expressing epithelia during kidney repair.
Article in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition.Nature communications · 2022Article
- Determining lineage relationships in kidney development and disease.Nature reviews. Nephrology · 2022Review
- Kidney Cells Regeneration: Dedifferentiation of Tubular Epithelium, Resident Stem Cells and Possible Niches for Renal Progenitors.International journal of molecular sciences · 2019Review
- Genetic Susceptibility to Chronic Kidney Disease - Some More Pieces for the Heritability Puzzle.Frontiers in genetics · 2019Review
- Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States.Oncotarget · 2017Article
- Comparing adult renal stem cell identification, characterization and applications.Journal of biomedical science · 2017Review
- Stem cells: potential and challenges for kidney repair.American journal of physiology. Renal physiology · 2014Review
- Stromal cells in tissue homeostasis: balancing regeneration and fibrosis.Nature reviews. Nephrology · 2013Review
- C-kit(+) cells isolated from developing kidneys are a novel population of stem cells with regenerative potential.Stem cells (Dayton, Ohio) · 2013Article
- Regenerative medicine for the kidney: stem cell prospects & challenges.Clinical and translational medicine · 2013Article
- Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration.The Journal of pathology · 2013Article
- Mouse model of ischemic acute kidney injury: technical notes and tricks.American journal of physiology. Renal physiology · 2012Review
- Renal stem cells: fact or science fiction?The Biochemical journal · 2012Review
- Association between kidney function and telomere length: the heart and soul study.American journal of nephrology · 2012Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
After acute kidney injury, mice with short telomeres develop increased damage with reduced proliferative capacity, which suggests an important role for telomere length in kidney repair. The enzyme telomerase reverse transcriptase (mTert) regulates telomere length; embryonic stem cells and certain adult stem cells express mTert, but whether cells in the adult kidney express mTert and whether these cells play a role in renal repair are unknown. Here, we found that telomerase protein and mRNA were highly enriched in renal papilla, a proposed niche of kidney stem cells. Using mTert-GFP reporter mice, we detected mTert in a subset of papillary epithelial cells comprising the collecting duct predominantly but also the loop of Henle. Approximately 5% of mTert-GFP(+) cells were label retaining, a characteristic of stem cells. mTert mRNA levels increased in renal papilla after ischemia-reperfusion injury, but genetically labeled mTert-expressing papillary cells neither divided nor migrated out of the renal papilla during kidney repair. In summary, these data suggest that cells expressing telomerase reverse transcriptase are not a progenitor-cell population, and they do not play a direct role in kidney repair.
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Registered trials
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