ArticleJournal of the American Society of Nephrology : JASN2012
Reduced expression of lipoic acid synthase accelerates diabetic nephropathy.
Article in Journal of the American Society of Nephrology : JASN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Effects of valsartan combined with α-lipoic acid on renal function in patients with diabetic nephropathy: a systematic review and meta-analysis.BMC endocrine disorders · 2021Pooled it
- Impacts of Metabolic Reprogramming on the Onset of Diabetic Nephropathy in Mice With Varying Lias Gene Expression Levels.Diabetes · 2025Article
- Drug-Induced Membranous Nephropathy: Piecing Together Clues to Understand Disease Mechanisms.Journal of the American Society of Nephrology : JASN · 2025Review
- The Association of Lipoic Acid Synthase (Journal of diabetes research · 2025Article
- Renal Endothelial Single-Cell Transcriptomics Reveals Spatiotemporal Regulation and Divergent Roles of Differential Gene Transcription and Alternative Splicing in Murine Diabetic Nephropathy.International journal of molecular sciences · 2024Article
- Bioinformatics reveals diagnostic potential of cuproptosis-related genes in the pathogenesis of sepsis.Heliyon · 2024Article
- Alpha-lipoic acid: A promising pharmacotherapy seen through the lens of kidney diseases.Current research in pharmacology and drug discovery · 2024Review
- Alpha-lipoic acid could attenuate the effect of chemerin-induced diabetic nephropathy progression.Iranian journal of basic medical sciences · 2021Article
- Overexpression of lipoic acid synthase gene alleviates diabetic nephropathyBMJ open diabetes research & care · 2021Article
- Microbial and metabolic impacts of trehalose and trehalose analogues.Gut microbes · 2020Article
- Oxidative Stress, Apoptosis, and Mitochondrial Function in Diabetic Nephropathy.International journal of endocrinology · 2018Review
- Variations in MicroRNA-25 Expression Influence the Severity of Diabetic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2017Article
- Influence of Different Levels of Lipoic Acid Synthase Gene Expression on Diabetic Nephropathy.PloS one · 2016Article
- Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse.The Journal of physiology · 2014Article
- Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway.International journal of endocrinology · 2014Article
- Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases.Diabetology & metabolic syndrome · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Oxidative stress contributes to the pathogenesis of diabetic nephropathy. In mitochondria, lipoic acid synthase produces α-lipoic acid, an antioxidant and an essential cofactor in α-ketoacid dehydrogenase complexes, which participate in glucose oxidation and ATP generation. Administration of lipoic acid abrogates diabetic nephropathy in animal models, but whether lower production of endogenous lipoic acid promotes diabetic nephropathy is unknown. Here, we crossed mice heterozygous for lipoic acid synthase deficiency (Lias(+/-)) with Ins2(Akita/+) mice, a well characterized model of type 1 diabetes. Double mutant mice had more overt diabetic nephropathy, including microalbuminuria, glomerular basement thickening, mesangial matrix expansion, and hypertension, compared with Lias(+/+)Ins2(Akita/+) controls. We also identified proximal tubules as a major site for generation of superoxide anions during diabetic nephropathy. Mitochondria in proximal tubular cells were particularly sensitive to damage in diabetic mice with reduced lipoic acid production. These results suggest that lipoic acid synthase deficiency increases oxidative stress and accelerates the development of diabetic nephropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.