ArticleThe Plant cell2011
Single cystathionine β-synthase domain-containing proteins modulate development by regulating the thioredoxin system in Arabidopsis.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 121 citations in OpenAlex.
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- Modulation of the wheat transcriptome by TaZFP13D under well-watered and drought conditions.Plant molecular biology · 2024Article
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- CBSX2 is required for the efficient oxidation of chloroplast redox-regulated enzymes in darkness.Plant direct · 2023Article
- QTL Verification and Candidate Gene Screening of Fiber Quality and Lint Percentage in the Secondary Segregating Population ofPlants (Basel, Switzerland) · 2023Article
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- Microbe-Responsive Proteomes During Plant-Microbe Interactions Between Rice Genotypes and the Multifunctional Methylobacterium oryzae CBMB20.Rice (New York, N.Y.) · 2023Article
- RNA-seq analysis and reconstruction of gene networks involved in response to salinity stress in quinoa (cv. Titicaca).Scientific reports · 2023Article
- Nodule-specific energy sensors determine symbiotic nitrogen fixation by regulating phosphoenolpyruvate allocation.Science China. Life sciences · 2023Article
- NewAntioxidants (Basel, Switzerland) · 2022Article
- Glutathione S-transferase interactions enhance wheat resistance to powdery mildew but not wheat stripe rust.Plant physiology · 2022Article
- Identification of quantitative trait loci for tillering, root, and shoot biomass at the maximum tillering stage in rice.Scientific reports · 2022Article
- Adenylates regulate Arabidopsis plastidial thioredoxin activities through the binding of a CBS domain protein.Plant physiology · 2022Article
- Genetic Conservation of CBS Domain Containing Protein Family inInternational journal of molecular sciences · 2022Article
- Functions of Redox Signaling in Pollen Development and Stress Response.Antioxidants (Basel, Switzerland) · 2022Review
- Genome-wide characterization of cys-tathionine-β-synthase domain-containing proteins in sugarcane reveals their role in defense responses under multiple stressors.Frontiers in plant science · 2022Article
- Type-A response regulators negatively mediate heat stress response by altering redox homeostasis in Arabidopsis.Frontiers in plant science · 2022Article
- Proteomic responses of two spring wheat cultivars to the combined water deficit and aphid (Frontiers in plant science · 2022Article
Corrections and comments
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- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant thioredoxins (Trxs) participate in two redox systems found in different cellular compartments: the NADP-Trx system (NTS) in the cytosol and mitochondria and the ferredoxin-Trx system (FTS) in the chloroplast, where they function as redox regulators by regulating the activity of various target enzymes. The identities of the master regulators that maintain cellular homeostasis and modulate timed development through redox regulating systems have remained completely unknown. Here, we show that proteins consisting of a single cystathionine β-synthase (CBS) domain pair stabilize cellular redox homeostasis and modulate plant development via regulation of Trx systems by sensing changes in adenosine-containing ligands. We identified two CBS domain-containing proteins in Arabidopsis thaliana, CBSX1 and CBSX2, which are localized to the chloroplast, where they activate all four Trxs in the FTS. CBSX3 was found to regulate mitochondrial Trx members in the NTS. CBSX1 directly regulates Trxs and thereby controls H(2)O(2) levels and regulates lignin polymerization in the anther endothecium. It also affects plant growth by regulating photosynthesis-related [corrected] enzymes, such as malate dehydrogenase, via homeostatic regulation of Trxs. Based on our findings, we suggest that the CBSX proteins (or a CBS pair) are ubiquitous redox regulators that regulate Trxs in the FTS and NTS to modulate development and maintain homeostasis under conditions that are threatening to the cell.
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