ArticleNucleic acids research2012
XNP/dATRX interacts with DREF in the chromatin to regulate gene expression.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Set2 and H3K36 regulate the Drosophila male X chromosome in a context-specific manner, independent from MSL complex spreading.Genetics · 2024Article
- Set2 and H3K36 regulate thebioRxiv : the preprint server for biology · 2024Article
- Phenotypic and transcriptomic impact of expressing mammalian TET2 in theEpigenetics · 2023Article
- Multiple Roles of dXNP and dADD1-International journal of molecular sciences · 2023Review
- The Molecular Properties and Roles ofFrontiers in physiology · 2022Article
- ZBED1/DREF: A transcription factor that regulates cell proliferation.Oncology letters · 2020Review
- Molecular effects of dADD1 misexpression in chromatin organization and transcription.BMC molecular and cell biology · 2020Article
- Chromatin Remodelers in the 3D Nuclear Compartment.Frontiers in genetics · 2020Review
- DREF Genetically Counteracts Mi-2 and Caf1 to Regulate Adult Stem Cell Maintenance.PLoS genetics · 2019Article
- Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers.PloS one · 2018Article
- dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.Chromosoma · 2017Article
- The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila.Nature communications · 2017Article
- Article
- The Hippo pathway as a target of the Drosophila DRE/DREF transcriptional regulatory pathway.Scientific reports · 2014Article
- Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs.Genes & development · 2014Article
- Article
- Single-cell analysis of Daxx and ATRX-dependent transcriptional repression.Journal of cell science · 2012Article
- Physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA repair/transcription factor TFIIH.The Journal of biological chemistry · 2012Article
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Authors and funding
8 authors.
Funding
Abstract
The ATRX gene encodes a chromatin remodeling protein that has two important domains, a helicase/ATPase domain and a domain composed of two zinc fingers called the ADD domain. The ADD domain binds to histone tails and has been proposed to mediate their binding to chromatin. The putative ATRX homolog in Drosophila (XNP/dATRX) has a conserved helicase/ATPase domain but lacks the ADD domain. In this study, we propose that XNP/dATRX interacts with other proteins with chromatin-binding domains to recognize specific regions of chromatin to regulate gene expression. We report a novel functional interaction between XNP/dATRX and the cell proliferation factor DREF in the expression of pannier (pnr). DREF binds to DNA-replication elements (DRE) at the pnr promoter to modulate pnr expression. XNP/dATRX interacts with DREF, and the contact between the two factors occurs at the DRE sites, resulting in transcriptional repression of pnr. The occupancy of XNP/dATRX at the DRE, depends on DNA binding of DREF at this site. Interestingly, XNP/dATRX regulates some, but not all of the genes modulated by DREF, suggesting a promoter-specific role of XNP/dATRX in gene regulation. This work establishes that XNP/dATRX directly contacts the transcriptional activator DREF in the chromatin to regulate gene expression.
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