Evidence map›Paper›PMID 22021312›Full record

ArticleAmerican journal of public health2011

Critical biological pathways for chronic psychosocial stress and research opportunities to advance the consideration of stress in chemical risk assessment.

Bruce S McEwen, Pamela Tucker

Abstract read
In one paragraph

Article in American journal of public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Local Violence as an Environmental Exposure with Increasing Relevance under Climate Change: A Conceptual Framework.Journal of urban health : bulletin of the New York Academy of Medicine · 2026
    Review
  5. Mental Health in Spanish Veterinarians: Emotional Exhaustion, Affective Symptomatology, and Suicidal Ideation.European journal of investigation in health, psychology and education · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Living Near Contamination: The Impacts on Personal Well-Being.Applied research in quality of life · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bruce S McEwenHarold and Margaret Milliken Hatch Laboratory of Neuroendrocrinology, Rockefeller University, New York, NY, USA.
Pamela Tucker

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests that psychosocial stress and toxicants may interact to modify health risks. Stress-toxicant interactions could be important in chemical risk assessment, but these interactions are poorly understood and additional research is necessary to advance their application. Environmental health research can increase knowledge of these interactions by exploring hypotheses on allostatic load, which measures the cumulative impacts of stress across multiple physiological pathways, using knowledge about physiological pathways for stress-related health effects, and evidence of common target pathways for both stress and toxicants. In this article, critical physiological pathways for stress-related health effects are discussed, with specific attention to allostatic load and stress-toxicant interactions, concluding with research suggestions for potential applications of such research in chemical risk assessment.

Indexed as

AllostasisBiomedical ResearchChronic DiseaseCritical PathwaysHazardous SubstancesHumansRisk AssessmentSocioeconomic FactorsStress, PsychologicalHazardous Substances

Identifiers

PMID22021312
PMCPMC3222511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.