ArticleHuman brain mapping2013
Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype.
Article in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- A Systematic Review of Candidate Genes for Major Depression.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Confining the Concept of Vascular Depression to Late-Onset Depression: A Meta-Analysis of MRI-Defined Hyperintensity Burden in Major Depressive Disorder and Bipolar Disorder.Frontiers in psychology · 2019Pooled it
- Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review.International journal of molecular sciences · 2016Pooled it
- Influences of resting-state intrinsic functional brain connectivity on the antidepressant treatment response in late-life depression.Psychological medicine · 2023Trial
- Integrative gene target mapping, RNA sequencing, in silico molecular docking, ADMET profiling and molecular dynamics simulation study of marine derived molecules for type 1 diabetes mellitus.Molecular diversity · 2026Article
- Cognitive, Disability, and Treatment Outcome Implications of Symptom-Based Phenotyping in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Biological factors influencing depression in later life: role of aging processes and treatment implications.Translational psychiatry · 2023Review
- EPI susceptibility correction introduces significant differences far from local areas of high distortion.Magnetic resonance imaging · 2022Article
- The enigma of vascular depression in old age: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Perspectives on the complex links between depression and dementia.Frontiers in aging neuroscience · 2022Review
- Pathomechanisms of Vascular Depression in Older Adults.International journal of molecular sciences · 2021Review
- Brain-based mechanisms of late-life depression: Implications for novel interventions.Seminars in cell & developmental biology · 2021Review
- Genetic polymorphisms in the renin-angiotensin system and cognitive decline in Parkinson's disease.Molecular biology reports · 2021Article
- Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations.Psychiatry investigation · 2020Article
- Cognitive Reserve Moderates Effects of White Matter Hyperintensity on Depressive Symptoms and Cognitive Function in Late-Life Depression.Frontiers in psychiatry · 2020Article
- Mechanisms and treatment of late-life depression.Translational psychiatry · 2019Review
- Polygenic Risk for Depression Increases Risk of Ischemic Stroke: From the Stroke Genetics Network Study.Stroke · 2018Article
- The Multi-Faceted Relationship between White Matter Lesions and Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- Vascular depression consensus report - a critical update.BMC medicine · 2016Article
- Brain structural connectivity in late-life major depressive disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Past work demonstrated that late-life depression is associated with greater severity of ischemic cerebral hyperintense white matter lesions, particularly frontal lesions. However, these lesions are also associated with other neuropsychiatric deficits, so these clinical relationships may depend on which fiber tracts are damaged. We examined the ratio of lesion to nonlesioned white matter tissue within multiple fiber tracts between depressed and nondepressed elders. We also sought to determine if the AGTR1 A1166C and BDNF Val66Met polymorphisms contributed to vulnerability to lesion development in discrete tracts. The 3T structural MR images and blood samples for genetic analyses were acquired on 54 depressed and 37 nondepressed elders. Lesion maps were created through an automated tissue segmentation process and applied to a probabilistic white matter fiber tract atlas allowing for identification of the fraction of the tract occupied by lesion. The depressed cohort exhibited a significantly greater lesion ratio only in the left upper cingulum near the cingulate gyrus (F((1,86)) = 4.62, P = 0.0344), supporting past work implicating cingulate dysfunction in the pathogenesis of depression. In the 62 Caucasian subjects with genetic data, AGTR1 C1166 carriers exhibited greater lesion ratios across multiple tracts including the anterior thalamic radiation and inferior fronto-occipital fasciculus. In contrast, BDNF Met allele carriers exhibited greater lesion ratios only in the frontal corpus callosum. Although these findings did not survive correction for multiple comparisons, this study supports our hypothesis and provides preliminary evidence that genetic differences related to vascular disease may increase lesion vulnerability differentially across fiber tracts.
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