ArticleHuman brain mapping2013
Brain growth rate abnormalities visualized in adolescents with autism.
Article in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Carbon Dot Nanoparticle-based Therapeutic Approaches in Major Neurological Disorders.Mini reviews in medicinal chemistry · 2026Review
- Neurobiological and Behavioral Heterogeneity in Adolescents with Autism Spectrum Disorder.Brain sciences · 2025Review
- A revisit of the amygdala theory of autism: Twenty years after.Neuropsychologia · 2023Review
- Applications of Various Types of Nanomaterials for the Treatment of Neurological Disorders.Nanomaterials (Basel, Switzerland) · 2022Review
- Functional and Neuropathological Evidence for a Role of the Brainstem in Autism.Frontiers in integrative neuroscience · 2021Article
- Parsing the Heterogeneity of Brain Metabolic Disturbances in Autism Spectrum Disorder.Biological psychiatry · 2020Article
- Progressive brain atrophy in chronically infected and treated HIV+ individuals.Journal of neurovirology · 2019Article
- Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood.Autism research : official journal of the International Society for Autism Research · 2019Article
- GeneAnalytics Pathways and Profiling of Shared Autism and Cancer Genes.International journal of molecular sciences · 2019Article
- Stressful Life Events, ADHD Symptoms, and Brain Structure in Early Adolescence.Journal of abnormal child psychology · 2019Article
- Effects of Dance Movement Therapy on Adult Patients with Autism Spectrum Disorder: A Randomized Controlled Trial.Behavioral sciences (Basel, Switzerland) · 2018Article
- An altered scaffold for information processing: Cognitive control development in adolescents with autism.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Calretinin interneuron density in the caudate nucleus is lower in autism spectrum disorder.Brain : a journal of neurology · 2017Article
- A Comparison of Structural Brain Imaging Findings in Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder.Neuropsychology review · 2016Review
- Studying Autism Spectrum Disorder with Structural and Diffusion Magnetic Resonance Imaging: A Survey.Frontiers in human neuroscience · 2016Review
- Sleep Spindle Characteristics in Children with Neurodevelopmental Disorders and Their Relation to Cognition.Neural plasticity · 2016Review
- Prevalence of Autism Spectrum Disorders in Ecuador: A Pilot Study in Quito.Journal of autism and developmental disorders · 2015Article
- Assessing hippocampal development and language in early childhood: Evidence from a new application of the Automatic Segmentation Adapter Tool.Human brain mapping · 2015Article
- Altered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder.Brain and behavior · 2015Article
- Brain imaging research in autism spectrum disorders: in search of neuropathology and health across the lifespan.Current opinion in psychiatry · 2015Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Autism spectrum disorder is a heterogeneous disorder of brain development with wide ranging cognitive deficits. Typically diagnosed before age 3, autism spectrum disorder is behaviorally defined but patients are thought to have protracted alterations in brain maturation. With longitudinal magnetic resonance imaging (MRI), we mapped an anomalous developmental trajectory of the brains of autistic compared with those of typically developing children and adolescents. Using tensor-based morphometry, we created 3D maps visualizing regional tissue growth rates based on longitudinal brain MRI scans of 13 autistic and seven typically developing boys (mean age/interscan interval: autism 12.0 ± 2.3 years/2.9 ± 0.9 years; control 12.3 ± 2.4/2.8 ± 0.8). The typically developing boys demonstrated strong whole brain white matter growth during this period, but the autistic boys showed abnormally slowed white matter development (P = 0.03, corrected), especially in the parietal (P = 0.008), temporal (P = 0.03), and occipital lobes (P = 0.02). We also visualized abnormal overgrowth in autism in gray matter structures such as the putamen and anterior cingulate cortex. Our findings reveal aberrant growth rates in brain regions implicated in social impairment, communication deficits and repetitive behaviors in autism, suggesting that growth rate abnormalities persist into adolescence. Tensor-based morphometry revealed persisting growth rate anomalies long after diagnosis, which has implications for evaluation of therapeutic effects.
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Registered trials
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