ArticleRNA (New York, N.Y.)2011
The silkworm W chromosome is a source of female-enriched piRNAs.
Article in RNA (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Molecular mechanisms of sex determination in Lepidoptera: current status and perspectives.Insect science · 2026Review
- Complete transition from chromosomal to cytoplasmic sex determination during prolonged Wolbachia symbiosis.Nature communications · 2026Article
- A W chromosome-derived feminizing piRNA in pyralid moths demonstrates convergent evolution for primary sex determination signals in Lepidoptera.BMC biology · 2025Article
- Polyommatine Blue Butterflies Reveal Unexpected Integrity of the W Sex Chromosome Amid Extensive Chromosomal Fragmentation Linked to Telomere Restoration.Genome biology and evolution · 2025Article
- Multiple independent origins of the female W chromosome in moths and butterflies.Science advances · 2024Article
- Review
- First characterization of PIWI-interacting RNA clusters in a cichlid fish with a B chromosome.BMC biology · 2022Article
- SilkBase: an integrated transcriptomic and genomic database for Bombyx mori and related species.Database : the journal of biological databases and curation · 2022Article
- Accumulation and ineffective silencing of transposable elements on an avian W Chromosome.Genome research · 2022Article
- Functional Characterization of Silkworm PIWI Proteins by Embryonic RNAi.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Identification and Characterization of the Masculinizing Function of theInternational journal of molecular sciences · 2021Article
- The Sex Determination Cascade in the Silkworm.Genes · 2021Review
- Gtsf1 is essential for proper female sex determination and transposon silencing in the silkworm, Bombyx mori.PLoS genetics · 2020Article
- Spliceosomal Protein GeneInternational journal of molecular sciences · 2020Article
- miRNA-1-3p is an early embryonic male sex-determining factor in the Oriental fruit fly Bactrocera dorsalis.Nature communications · 2020Article
- Article
- P-element Somatic Inhibitor Protein Binding a Target Sequence inInternational journal of molecular sciences · 2019Article
- A new approach for comprehensively describing heterogametic sex chromosomes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Bombyx mori histone methyltransferase BmAsh2 is essential for silkworm piRNA-mediated sex determination.PLoS genetics · 2018Article
- The genome of the Hi5 germ cell line fromeLife · 2018Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the silkworm, Bombyx mori, the W chromosome plays a dominant role in female determination. However, neither protein-coding genes nor transcripts have so far been isolated from the W chromosome. Instead, a large amount of functional transposable elements and their remnants are accumulated on the W chromosome. PIWI-interacting RNAs (piRNAs) are 23-30-nt-long small RNAs that potentially act as sequence-specific guides for PIWI proteins to silence transposon activity in animal gonads. In this study, by comparing ovary- and testis-derived piRNAs, we identified numerous female-enriched piRNAs. Our data indicated that female-enriched piRNAs are derived from the W chromosome. Moreover, comparative analyses on piRNA profiles from a series of W chromosome mutant strains revealed a striking enrichment of a specific set of transposon-derived piRNAs in the putative sex-determining region. Collectively, we revealed the nature of the silkworm W chromosome as a source of piRNAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.