ReviewSpine2011
The potential contribution of stress systems to the transition to chronic whiplash-associated disorders.
Review in Spine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- The effect of steroid treatment on whiplash associated syndrome: a controlled randomized prospective trial.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Trial
- Trial
- Personalized Multimodal Lifestyle Intervention as the Best-Evidenced Treatment for Chronic Pain: State-of-the-Art Clinical Perspective.Journal of clinical medicine · 2024Review
- CpG Methylation Levels in HPA Axis Genes Predict Chronic Pain Outcomes Following Trauma Exposure.The journal of pain · 2023Article
- Duration of Reduction in Enduring Stress-Induced Hyperalgesia Via FKBP51 Inhibition Depends on Timing of Administration Relative to Traumatic Stress Exposure.The journal of pain · 2022Article
- Cervical Motor and Nociceptive Dysfunction After an Acute Whiplash Injury and the Association With Long-Term Non-Recovery: Revisiting a One-Year Prospective Cohort With Ankle Injured Controls.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Posttraumatic Stress Symptoms and Pain Sensitization After Whiplash Injury: A Longitudinal Cohort Study With Quantitative Sensory Testing.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Can cortisol levels predict the severity of acute whiplash-associated disorders?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Observational
- Hypertension prevalence in patients attending tertiary pain management services, a registry-based Australian cohort study.PloS one · 2020Article
- Early Screening for Posttraumatic Stress Disorder and Depression Among Injured Emergency Department Patients: A Feasibility Study.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2019Article
- Are Magnetic Resonance Imaging Technologies Crucial to Our Understanding of Spinal Conditions?The Journal of orthopaedic and sports physical therapy · 2019Article
- The relation between local and distal muscle fat infiltration in chronic whiplash using magnetic resonance imaging.PloS one · 2019Article
- A Functional riboSNitch in the 3' Untranslated Region ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.Anesthesiology · 2018Review
- Co-occurrence of posttraumatic stress symptoms, pain, and disability 12 months after traumatic injury.Pain reports · 2017Article
- An Integrated Model of Chronic Whiplash-Associated Disorder.The Journal of orthopaedic and sports physical therapy · 2017Article
- Article
- Advancements in Imaging Technology: Do They (or Will They) Equate to Advancements in Our Knowledge of Recovery in Whiplash?The Journal of orthopaedic and sports physical therapy · 2016Article
- Persistent Pain Among Older Adults Discharged Home From the Emergency Department After Motor Vehicle Crash: A Prospective Cohort Study.Annals of emergency medicine · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
STUDY
designA narrative description highlighting preclinical and clinical evidence that physiologic stress systems contribute to whiplash-associated disorders (WAD) pathogenesis.
objectiveTo present several lines of evidence supporting the hypothesis that physiologic stress systems contribute to WAD pathogenesis. SUMMARY OF BACKGROUND DATA: In addition to subjecting soft tissue to biomechanical strain, a motor vehicle collision (MVC) event is also an acute stressor which activates physiologic stress systems. Increasing data from animal and human studies suggest that the activation of these stress systems may contribute to long-lasting changes in pain sensitivity after tissue injury.
methodsNonsystematic review of several lines of evidence that together suggest that physiologic systems involved in the stress response may contribute to the development of WAD.
resultsStress systems which appear capable of producing hyperalgesia and allodynia include catecholaminergic systems, serotonin systems, and the hypothalamic-pituitary-adrenocortical system. Evidence for the role of these systems comes, in part, from studies examining the association between genetic variants and chronic pain outcomes. For example, in a recent study of acute neck pain after MVC, patients with certain genotypes of an enzyme involved in catecholamine metabolism were more than twice as likely to report moderate or severe neck pain in the emergency department. Such pain vulnerability because of stress system function may interact with the effects of biomechanical injury and psychobehavioral responses to influence the development of WAD.
conclusionMore research examining the influence of stress systems on WAD are needed. If these systems do influence WAD outcomes, then treatments which diminish the adverse effects of stress systems may be a useful component of multimodal therapeutic interventions for individuals at risk of chronic pain development after MVC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.