ArticleApplied and environmental microbiology2012
High frequency of a novel filamentous phage, VCY φ, within an environmental Vibrio cholerae population.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Article
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- Whole genome sequence of Vibrio cholerae NB-183 isolated from freshwater in Ontario, Canada harbors a unique gene repertoire.BMC genomic data · 2024Article
- Genomic analysis ofHeliyon · 2023Article
- Beyond Cholera: Characterization ofViruses · 2020Article
- Quorum Sensing Signals AlterFrontiers in microbiology · 2020Article
- Filamentous phages: masters of a microbial sharing economy.EMBO reports · 2019Review
- Diversification ofFrontiers in microbiology · 2019Article
- Article
- Diversity ofFrontiers in microbiology · 2017Article
- Physiological Properties and Genome Structure of the Hyperthermophilic Filamentous Phage φOH3 Which Infects Thermus thermophilus HB8.Frontiers in microbiology · 2016Article
- From cholera to corals: Viruses as drivers of virulence in a major coral bacterial pathogen.Scientific reports · 2015Article
- Filamentous phages prevalent in Pseudoalteromonas spp. confer properties advantageous to host survival in Arctic sea ice.The ISME journal · 2015Article
- Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold.Frontiers in microbiology · 2015Review
- Isolation and characterization of the new mosaic filamentous phage VFJ Φ of Vibrio cholerae.PloS one · 2013Article
- Filamentous phages of Ralstonia solanacearum: double-edged swords for pathogenic bacteria.Frontiers in microbiology · 2013Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Environmental Vibrio cholerae strains isolated from a coastal brackish pond (Oyster Pond, Woods Hole, MA) carried a novel filamentous phage, VCY, which can exist as a host genome integrative form (IF) and a plasmid-like replicative form (RF). Outside the cell, the phage displays a morphology typical of Inovirus, with filamentous particles ∼1.8 μm in length and 7 nm in width. Four independent RF isolates had identical genomes, except for 8 single nucleotide polymorphisms clustered in two regions. The overall genome size is 7,103 bp with 11 putative open reading frames organized into three functional modules (replication, structure and assembly, and regulation). VCY shares sequence similarity with other filamentous phages (including cholera disease-associated CTX) in a highly mosaic manner, indicating evolution by horizontal gene transfer and recombination. VCY integrates in the vicinity of the putative translation initiation factor Sui1 in chromosome II of V. cholerae. A screen of 531 closely related host isolates showed that ∼40% harbored phages, with 27% and 13% carrying the IF and RF, respectively. The relative frequencies of the RF and IF differed among strains isolated from the pond or lagoon of Oyster Pond, suggesting that the host habitat influences intracellular phage biology. The overall high prevalence within the host population shows that filamentous phages can be an important component of the environmental biology of V. cholerae.
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