ArticleCritical care medicine2012
The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock.
Article in Critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00257231 (Inflammation and the Host Response to Injury), which is not on this map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Inflammation and the Host Response to Injury
Who cites it
76 citing papers in PubMed, 158 citations in OpenAlex.
- Safety and efficacy of artesunate treatment in severely injured patients with traumatic hemorrhage. The TOP-ART randomized clinical trial.Intensive care medicine · 2023Trial
- P2X4 receptors on myeloid cells mediate tissue injury in a model of trauma and hemorrhagic shock in male mice.Purinergic signalling · 2026Article
- P2X4 receptors on myeloid cells mediate tissue injury in a murine model of trauma and hemorrhagic shock.Research square · 2025Article
- Fibrinogen based resuscitation mitigates lung injury in mice with bacterial pneumonia after hemorrhagic shock.Biochemistry and biophysics reports · 2025Article
- TBI related death has become the new epidemic in polytrauma: a 10-year prospective cohort analysis in severely injured patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Epidemiology of postinjury multiple organ failure: a prospective multicenter observational study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Observational
- Development of a biomarker prediction model for post-trauma multiple organ failure/dysfunction syndrome based on the blood transcriptome.Annals of intensive care · 2024Article
- Predictive value of laboratory indicators for in-hospital death in children with community-onset sepsis: a prospective observational study of 266 patients.BMJ paediatrics open · 2024Observational
- Postinjury multiple organ failure in polytrauma: more frequent and potentially less deadly with less crystalloid.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Characterization of multiple organ failure after ruptured abdominal aortic aneurysm repair.Journal of vascular surgery · 2023Article
- Articles on hemorrhagic shock published between 2000 and 2021: A CiteSpace-Based bibliometric analysis.Heliyon · 2023Article
- Evaluation of critical care burden following traumatic injury from two randomized controlled trials.Scientific reports · 2023Article
- [Early changes within the lymphocyte population are associated with the long term prognosis in severely injured patients].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Genetic and immune crosstalk between severe burns and blunt trauma: A study of transcriptomic data.Frontiers in genetics · 2022Article
- Cigarette smoke exposure reduces hemorrhagic shock induced circulatory dysfunction in mice with attenuated glucocorticoid receptor function.Frontiers in immunology · 2022Article
- Influence of surgical stabilization of clavicle fractures in multiply-injured patients with thoracic trauma.Scientific reports · 2021Article
- Biological Connection of Psychological Stress and Polytrauma under Intensive Care: The Role of Oxytocin and Hydrogen Sulfide.International journal of molecular sciences · 2021Review
- Trauma-Induced Coagulopathy: Overview of an Emerging Medical Problem from Pathophysiology to Outcomes.Medicines (Basel, Switzerland) · 2021Review
- Spectral analysis of heart rate variability for trauma outcome prediction: an analysis of 210 ICU multiple trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Chronic critical illness after hypothermia in trauma patients.Trauma surgery & acute care open · 2021Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 8 institutions in 1 country.
Funding
Abstract
objectivesTo describe the incidence of postinjury multiple organ failure and its relationship to nosocomial infection and mortality in trauma centers using evidence-based standard operating procedures.
designProspective cohort study wherein standard operating procedures were developed and implemented to optimize postinjury care.
settingSeven U.S. level I trauma centers. PATIENTS: Severely injured patients (older than age 16 yrs) with a blunt mechanism, systolic hypotension (<90 mm Hg), and/or base deficit (≥6 mEq/L), need for blood transfusion within the first 12 hrs, and an abbreviated injury score ≥2 excluding brain injury were eligible for inclusion. MEASUREMENTS AND MAIN
resultsOne thousand two patients were enrolled and 916 met inclusion criteria. Daily markers of organ dysfunction were prospectively recorded for all patients while receiving intensive care. Overall, 29% of patients had multiple organ failure develop. Development of multiple organ failure was early (median time, 2 days), short-lived, and predicted an increased incidence of nosocomial infection, whereas persistence of multiple organ failure predicted mortality. However, surprisingly, nosocomial infection did not increase subsequent multiple organ failure and there was no evidence of a "second-hit"-induced late-onset multiple organ failure.
conclusionsMultiple organ failure remains common after severe injury. Contrary to current paradigms, the onset is only early, and not bimodal, nor is it associated with a "second-hit"-induced late onset. Multiple organ failure is associated with subsequent nosocomial infection and increased mortality. Standard operating procedure-driven interventions may be associated with a decrease in late multiple organ failure and morbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.