ArticleMechanisms of ageing and development
Leukocyte telomere length and physical ability among Danish twins age 70+.
Article in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921.Mechanisms of ageing and development · 2016Trial
- Analysis of Telomere Length and Its Implication in Neurocognitive Functions in Elderly Women.Journal of clinical medicine · 2022Article
- Telomere length as a function of age at population level parallels human survival curves.Aging · 2021Article
- The effect of a 12-week resistance training intervention on leukocyte telomere length.Heliyon · 2020Article
- Telomere length and cognitive function: Differential patterns across sociodemographic groups.Neuropsychology · 2020Article
- Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults.Frontiers in physiology · 2018Article
- Telomeres, Aging and Exercise: Guilty by Association?International journal of molecular sciences · 2017Review
- Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training.Sports medicine (Auckland, N.Z.) · 2016Review
- Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?Age (Dordrecht, Netherlands) · 2016Article
- Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men.Frontiers in aging neuroscience · 2016Article
- Targets of immune regeneration in rheumatoid arthritis.Mayo Clinic proceedings · 2014Review
- Changes in the frequencies of human hematopoietic stem and progenitor cells with age and site.Experimental hematology · 2014Article
- Association of leukocyte telomere length with fatigue in nondisabled older adults.Journal of aging research · 2014Article
- Genetics of healthy aging and longevity.Human genetics · 2013Review
- Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Leukocyte telomere length (LTL) shortens with age and is potentially a biomarker of human aging. We examined the relation of LTL with physical ability and cognitive function in 548 same-sex twins from the Longitudinal Study of Aging Danish Twins. LTL was measured by Southern blots of the terminal restriction fragments (TRF). Physical ability was evaluated using a self reported scale of 11 questions, while cognitive function was scored by MMSE and a cognitive composite score sensitive to age-related decline. A random intercept model revealed a positive, significant association between LTL and physical ability. For every unit increase in physical ability score, LTL increased by 0.066 kb (p = 0.01), equal to approximately three years of age-dependent LTL shortening. A matched case-co-twin design showed that the group consisting of the twins from each pair with the longer LTL also displayed better physical ability (p < 0.01). Moreover, the intra-pair difference in LTL was associated with intra-pair difference in physical ability (p < 0.01), confirming the association. However, we found no association between cognitive function and LTL. The LTL-physical ability association in the elderly provides further support to the premise that LTL is an index of somatic fitness in the narrow context of human physical health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.