Evidence map›Paper›PMID 22019906›Full record

ReviewCytokine & growth factor reviews2011

Understanding the mechanism of IL-1β secretion.

Gloria Lopez-Castejon, David Brough

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cytokine & growth factor reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 841 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
841citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

841 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Testosterone Modulates Virulence-Associated Phenotypes ofPathogens (Basel, Switzerland) · 2026
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  18. mBio · 2026
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781 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gloria Lopez-CastejonFaculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
David Brough

Funding

Biotechnology and Biological Sciences Research CouncilWellcome Trust
6 · The paper itself

Abstract

The cytokine interleukin-1β (IL-1β) is a key mediator of the inflammatory response. Essential for the host-response and resistance to pathogens, it also exacerbates damage during chronic disease and acute tissue injury. It is not surprising therefore that there is a huge level of interest in how this protein is produced and exported from cells. However, the mechanism of IL-1β release has proven to be elusive. It does not follow the conventional ER-Golgi route of secretion. A literature full of disparate observations arising from numerous experimental systems, has contributed to a complicated mix of diverse proposals. Here we summarise these observations and propose that secretion of IL-1β occurs on a continuum, dependent upon stimulus strength and the extracellular IL-1β requirement.

Indexed as

AnimalsHumansInflammationInterleukin-1betaSecretory PathwayIL1B protein, humanInterleukin-1beta

Identifiers

PMID22019906
PMCPMC3714593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.