ReviewMolecular and cellular endocrinology2012
The cAMP pathway and the control of adrenocortical development and growth.
Review in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- The Emerging Role of Aldosterone Synthase Inhibitors in Overcoming Renin-Angiotensin-Aldosterone System Therapy Limitations: A Narrative Review.Cardiac failure review · 2025Review
- Editorial: Cyclic nucleotide phosphodiesterases (PDEs) signaling in the endocrine system.Frontiers in endocrinology · 2025Article
- Current insight into the transient X-zone in the adrenal gland cortex.Vitamins and hormones · 2024Review
- Overview of endocrine tumor syndromes manifesting as adrenal tumors.Ewha medical journal · 2024Review
- Disorders of the adrenal cortex: Genetic and molecular aspects.Frontiers in endocrinology · 2022Review
- Adrenal cortex renewal in health and disease.Nature reviews. Endocrinology · 2021Review
- Cushing Syndrome in a Pediatric Patient With a KCNJ5 Variant and Successful Treatment With Low-dose Ketoconazole.The Journal of clinical endocrinology and metabolism · 2021Article
- Aldosterone-Regulating Receptors and Aldosterone-Driver Somatic Mutations.Frontiers in endocrinology · 2021Article
- ARMC5 variants in PRKAR1A-mutated patients modify cortisol levels and Cushing's syndrome.Endocrine-related cancer · 2020Article
- STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association.Frontiers in endocrinology · 2020Review
- The human adrenal cortex: growth control and disorders.Clinics (Sao Paulo, Brazil) · 2018Review
- The role of epithelial growth factors and insulin growth factors in the adrenal neoplasms.Annals of translational medicine · 2018Review
- Mouse models of adrenocortical tumors.Molecular and cellular endocrinology · 2016Review
- 5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer.Hormones & cancer · 2016Review
- The Role of gsp Mutations on the Development of Adrenocortical Tumors and Adrenal Hyperplasia.Frontiers in endocrinology · 2016Review
- Functional Zonation of the Adult Mammalian Adrenal Cortex.Frontiers in neuroscience · 2016Review
- Role of ACTH and Other Hormones in the Regulation of Aldosterone Production in Primary Aldosteronism.Frontiers in endocrinology · 2016Review
- Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?Frontiers in endocrinology · 2016Review
- Celecoxib reduces glucocorticoids in vitro and in a mouse model with adrenocortical hyperplasia.Endocrine-related cancer · 2016Article
- Toying with fate: Redirecting the differentiation of adrenocortical progenitor cells into gonadal-like tissue.Molecular and cellular endocrinology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
In the last 10 years, extensive studies showed that the cAMP pathway is deregulated in patients suffering from adrenocortical tumours, and particularly in primary pigmented nodular adrenocortical disease (PPNAD). Here we describe how evidence arising from the analysis of patients' data, mouse models and in vitro experiments, have shed light on the cAMP pathway as a central player in adrenal physiopathology. We also show how novel data generated from mouse models may point to new targets for potential therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.