ArticleAmerican journal of ophthalmology2012
Evaluation of vascular disease progression in retinopathy of prematurity using static and dynamic retinal images.
Article in American journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Variability in Plus Disease Diagnosis using Single and Serial Images.Ophthalmology. Retina · 2022Article
- Plus Disease in Retinopathy of Prematurity: Diagnostic Trends in 2016 Versus 2007.American journal of ophthalmology · 2017Article
- Telemedicine Applications in Pediatric Retinal Disease.Journal of clinical medicine · 2017Review
- Retinopathy of Prematurity: Imaging in retinopathy of prematurity: where are we, and where are we going?Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2016Article
- Plus Disease in Retinopathy of Prematurity: Improving Diagnosis by Ranking Disease Severity and Using Quantitative Image Analysis.Ophthalmology · 2016Article
- Teleophthalmology: improving patient outcomes?Clinical ophthalmology (Auckland, N.Z.) · 2016Review
- Comparison of retinal image evaluation techniques in novice clinicians.Journal of medical imaging (Bellingham, Wash.) · 2015Article
- Evaluation of electronic health record implementation in ophthalmology at an academic medical center (an American Ophthalmological Society thesis).Transactions of the American Ophthalmological Society · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo measure accuracy and speed for detection of vascular progression in retinopathy of prematurity (ROP) from serial images. Two strategies are compared: static side-by-side presentation and dynamic flickering of superimposed image pairs.
designProspective comparative study.
methodsFifteen de-identified, wide-angle retinal image pairs were taken from infants who eventually developed plus disease. Image pairs representing vascular disease progression were taken ≥1 week apart, and control images without progression were taken on the same day. Dynamic flickering pairs were created by digital image registration. Ten experts independently reviewed each image pair on a secure website using both strategies, and were asked to identify progression or state that images were identical. Accuracy and speed were measured, using examination date and ophthalmoscopic findings as a reference standard.
resultsUsing static images, experts were accurate in a mean (%) ± standard deviation (SD) of 11.4 of 15 (76%) ± 1.7 image pairs. Using dynamic flickering images, experts were accurate in a mean (%) ± SD of 11.3 of 15 (75%) ± 1.7 image pairs. There was no significant difference in accuracy between these strategies (P = .420). Diagnostic speed was faster using dynamic flickering (24.7 ± 8.3 seconds) vs static side-by-side images (40.3 ± 18.3 seconds) (P = .002). Experts reported higher confidence when interpreting dynamic flickering images (P = .001).
conclusionsRetinal imaging provides objective documentation of vascular appearance, with potentially improved ability to recognize ROP progression compared to standard ophthalmoscopy. Speed of identifying vascular progression was faster by review of dynamic flickering image pairs than by static side-by-side images, although there was no difference in accuracy.
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Registered trials
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