Evidence map›Paper›PMID 22019221›Full record

ArticleAmerican journal of ophthalmology2012

Retinal vessel caliber among people with acquired immunodeficiency syndrome: relationships with visual function.

Partho S Kalyani, Amani A Fawzi, Sapna Gangaputra, Mark L van Natta, Larry D Hubbard, Ronald P Danis, Jennifer E Thorne, Gary N Holland, Studies of the Ocular Complications of AIDS Research Group

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000168 (Studies of Ocular Complications of AIDS), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000168 completednot on this map

Studies of Ocular Complications of AIDS (SOCA)

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan1998 to 2013Enrolled2,392ConditionsHIV Infections, Acquired Immunodeficiency Syndrome, Cytomegalovirus Retinitis
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Observational
  5. HCV, but not HIV, is a risk factor for cerebral small vessel disease.Neurology(R) neuroimmunology & neuroinflammation · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Partho S KalyaniOcular Inflammatory Disease Center, Jules Stein Eye Institute, Los Angeles, California, USA.
Amani A Fawzi
Sapna Gangaputra
Mark L van Natta
Larry D Hubbard
Ronald P Danis
Jennifer E Thorne
Gary N Holland
Studies of the Ocular Complications of AIDS Research Group
University of Wisconsin–Madison · USDoheny Eye Institute · USJohns Hopkins University · USUniversity of Southern California · US

Funding

Studies of Ocular Complications of AIDS - Coordinating CenterU10EY008057 · NEI · JOHNS HOPKINS UNIVERSITY · PI VAN NATTA, MARK L · 1988 to 2012
$78.0M
ZOPOLRESTAT IN NORMOTENSIVE, TYPE 1 DIA WITH INCIPIENT NEPHROPATHYM01RR000043 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZAIA, JOHN A · 1985 to 2010
$76.4M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024996 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2007 to 2011
$49.6M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
Zonisamide in Patients with Neuropathic Pain Associated with Diabetic NeuropathyM01RR000046 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOY, MELANIE S · 1985 to 2008
$38.5M
ZOPOLRESTAT IN SUBJECTS W/ PERIPHERAL SYMMETRICAL DIABETIC POLYNEUROPATHYM01RR000096 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOVIK, YELENA · 1985 to 2008
$34.8M
ZENARESTAT IN DIABETIC NEUROPATHYM01RR005096 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI FONSECA, VIVIAN A · 1990 to 2006
$17.4M
WOMEN'S HEALTH AGENDAU01AI025868 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ERON, JOSEPH J. · 1987 to 2006
$14.9M
WOMEN'S HEALTH AGENDAU01AI027670 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BENSON, CONSTANCE ANN · 1988 to 2006
$13.7M
WOMEN'S HEALTH AGENDAU01AI032783 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI TEBAS, PABLO · 1992 to 2007
$11.9M
WOMEN'S HEALTH AGENDAU01AI027660 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CURRIER, JUDITH S. · 1988 to 2006
$11.8M
WOMEN'S HEALTH AGENDAU01AI027663 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAVLIR, DIANE V · 1988 to 2006
$11.4M
NCRR NIH HHS 5M01 RR00043NCRR NIH HHS 5M01 RR00046NCRR NIH HHS 5M01 RR00096NCRR NIH HHS 5M01 RR 00350NCRR NIH HHS 5M01 RR00865NCRR NIH HHS 5M01 RR 05096NCRR NIH HHS M01 RR000043NCRR NIH HHS M01 RR000046NCRR NIH HHS M01 RR000096NCRR NIH HHS M01 RR000865NCRR NIH HHS M01 RR005096NCRR NIH HHS UL1 RR024996NCRR NIH HHS ULI RR024996NEI NIH HHS U10 EY008052NEI NIH HHS U10 EY008057NEI NIH HHS U10 EY008067NEI NIH HHS U10 EY08052NEI NIH HHS U10 EY 08057NEI NIH HHS U10 EY 08067NIAID NIH HHS U01 AI025868NIAID NIH HHS U01 AI027660NIAID NIH HHS U01 AI027663NIAID NIH HHS U01 AI027670NIAID NIH HHS U01 AI032783NIAID NIH HHS U01 AI25868NIAID NIH HHS U01 AI 27660NIAID NIH HHS U01 AI 27663NIAID NIH HHS U01 AI 27670NIAID NIH HHS U01 AI 27674NIAID NIH HHS U01 AI32783
6 · The paper itself

Abstract

purposeTo evaluate relationships between retinal vessel caliber and tests of visual function among people with AIDS.

designLongitudinal, observational cohort study.

methodsWe evaluated data for participants without ocular opportunistic infections at initial examination (baseline) in the Longitudinal Studies of the Ocular Complications of AIDS (1998-2008). Visual function was evaluated with best-corrected visual acuity, Goldmann perimetry, automated perimetry (Humphrey Field Analyzer), and contrast sensitivity (CS) testing. Semi-automated grading of fundus photographs (1 eye/participant) determined central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and arteriole-to-venule ratio (AVR) at baseline. Multiple linear regression models, using forward selection, sought independent relationships between indices and visual function variables.

resultsIncluded were 1250 participants. Smaller AVR was associated with reduced visual field by Goldmann perimetry (P = .003) and worse mean deviation (P = .02) on automated perimetry and possibly with worse pattern standard deviation (PSD) on automated perimetry (P = .06). There was a weak association between smaller AVR and worse CS (P = .07). Relationships were independent of antiretroviral therapy and level of immunodeficiency (CD4+ T lymphocyte count, human immunodeficiency virus [HIV] RNA blood level). On longitudinal analysis, retinal vascular indices at baseline did not predict changes in visual function.

conclusionsVariation in retinal vascular indices is associated with abnormal visual function in people with AIDS, manifested by visual field loss and possibly by reduced CS. Relationships are consistent with the hypothesis that HIV-related retinal vasculopathy is a contributing factor to vision dysfunction among HIV-infected individuals. Longitudinal studies are needed to determine whether changes in indices predict change in visual function.

Indexed as

Acquired Immunodeficiency SyndromeAdultAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCD4-Positive T-LymphocytesCohort StudiesContrast SensitivityFemaleHIV-1HumansLongitudinal StudiesMaleMiddle AgedRetinal DiseasesRetinal VesselsRNA, ViralRNA, Viral

Identifiers

PMID22019221
PMCPMC4859428
OpenAlexW1996740561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.