ArticleCell metabolism2011
The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin.
Article in Cell metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- MicroRNA-147a Targets SLC40A1 to Induce Ferroptosis in Human Glioblastoma.Analytical cellular pathology (Amsterdam) · 2022Article
- Caloric restriction reverses left ventricular hypertrophy through the regulation of cardiac iron homeostasis in impaired leptin signaling mice.Scientific reports · 2020Article
- Ironing out Ferroportin.Cell metabolism · 2015Review
- Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans.Metallomics : integrated biometal science · 2015Article
- EGCG Protects against 6-OHDA-Induced Neurotoxicity in a Cell Culture Model.Parkinson's disease · 2015Article
- Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin.PLoS genetics · 2013Article
- Molecular insights into the regulation of iron metabolism during the prenatal and early postnatal periods.Cellular and molecular life sciences : CMLS · 2013Review
- Role of altered expression of Nedd4L in the pathogenesis of systemic malignancies.International journal of experimental pathology · 2012Article
- Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances.Biochimica et biophysica acta · 2012Review
- Ferroportin-mediated iron transport: expression and regulation.Biochimica et biophysica acta · 2012Review
- Protein degradation and iron homeostasis.Biochimica et biophysica acta · 2012Review
- Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.Cell metabolism · 2012Article
- Iron transport machinery of human cells: players and their interactions.Current topics in membranes · 2012Review
- The Role of Iron Metabolism in Lung Inflammation and Injury.Journal of allergy & therapy · 2012Article
Corrections and comments
- Retraction · 2012-06-06Concerns/Issues about Data · Duplication of/in Image · Error in Image · Falsification/Fabrication of Image · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Ivana De Domeinco aka Ivana Frech has ORI Finding of misconduct: see https://ori.hhs.gov/content/case-summary-de-domenico-ivana
- Commented on by
- Retracted
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The iron exporter ferroportin (Fpn) is essential to transfer iron from cells to plasma. Systemic iron homeostasis in vertebrates is regulated by the hepcidin-mediated internalization of Fpn. Here, we demonstrate a second route for Fpn internalization; when cytosolic iron levels are low, Fpn is internalized in a hepcidin-independent manner dependent upon the E3 ubiquitin ligase Nedd4-2 and the Nedd4-2 binding protein Nfdip-1. Retention of cell-surface Fpn through reductions in Nedd4-2 results in cell death through depletion of cytosolic iron. Nedd4-2 is also required for internalization of Fpn in the absence of ferroxidase activity as well as for the entry of hepcidin-induced Fpn into the multivesicular body. C. elegans lacks hepcidin genes, and C. elegans Fpn expressed in mammalian cells is not internalized by hepcidin but is internalized in response to iron deprivation in a Nedd4-2-dependent manner, supporting the hypothesis that Nedd4-2-induced internalization of Fpn is evolutionarily conserved.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.